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Placebo effects on analgesia related to testosterone and premotor activation

Authors
 Jae Chan Choi ; Do-Joon Yi ; Bo-Hyun Kim ; Ji Hyun Kim ; Phil Hyu Lee ; Bong Soo Han 
Citation
 Neuroreport, Vol.22(9) : 419~423, 2011 
Journal Title
 Neuroreport 
ISSN
 0959-4965 
Issue Date
2011
Abstract
Using functional magnetic resonance imaging, we tested whether graded placebo conditions could modulate the degree of placebo effect and brain activation patterns in study participants and whether the placebo effect could be influenced by hormones. Each participant was investigated under three conditions: the control (no placebo) condition, the low-placebo condition, and the high-placebo condition (HPC). Activations of the premotor areas, anterior cingulate cortex, and prefrontal cortex were stronger in the HPC compared with those in the control and low placebo conditions. The premotor areas were activated by increased testosterone levels under the HPC. These results suggest that testosterone may affect the brain activation and response to pain during a high-placebo response, with the data supported by brain imaging.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/92877
DOI
10.1097/WNR.0b013e32834601c9
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Neurology
Yonsei Authors
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Link
 http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00001756-201106220-00002&D=ovft&PDF=y
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