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Clinical significance of a large difference (≥ 2 points) between biopsy and post-prostatectomy pathological Gleason scores in patients with prostate cancer.

Authors
 Changhee Yoo  ;  Cheol Young Oh  ;  Jin Seon Cho  ;  Cheryn Song  ;  Seong Il Seo  ;  Hanjong Ahn  ;  Tae-Kon Hwang  ;  Jun Cheon  ;  Kang Hyun Lee  ;  Tae Gyun Kwon  ;  Tae Young Jung  ;  Moon Kee Chung  ;  Sang Eun Lee  ;  Hyun Moo Lee  ;  Eun Sik Lee  ;  Young Deuk Choi  ;  Byung Ha Chung  ;  Hyung Jin Kim  ;  Wun-Jae Kim  ;  Seok-Soo Byun  ;  Han Yong Choi 
Citation
 JOURNAL OF KOREAN MEDICAL SCIENCE, Vol.26(4) : 507-512, 2011 
Journal Title
 JOURNAL OF KOREAN MEDICAL SCIENCE 
ISSN
 1011-8934 
Issue Date
2011
MeSH
Age Factors ; Aged ; Biopsy ; Humans ; Male ; Middle Aged ; Multivariate Analysis ; Neoplasm Staging ; Prognosis ; Prostatectomy* ; Prostatic Neoplasms/pathology* ; Prostatic Neoplasms/surgery ; Recurrence ; Severity of Illness Index
Keywords
Prostatic Neoplasms ; Gleason Score ; Prognosis
Abstract
We investigated the clinical significance of large difference (≥ 2 points) between biopsy-derived (bGS) and post-prostatectomy Gleason scores (pGS). At 14 medical centers in Korea, 1,582 men who underwent radical prostatectomy for prostate cancer were included. According to the difference between bGS and pGS, the patients were divided into three groups: A (decreased in pGS ≥ 2, n = 30), B (changed in pGS ≤ 1, n = 1,361; control group), and C (increased in pGS ≥ 2, n = 55). We evaluated various clinicopathological factors of prostate cancer and hazards for biochemical failure. Group A showed significantly higher mean maximal percentage of cancer in the positive cores (max%) and pathological T stage than control. In group C, the number of biopsy core was significantly smaller, however, tumor volume and max% were significantly higher and more positive biopsy cores were presented than control. Worse pathological stage and more margin-positive were observed in group A and C than in control. Hazard ratio for biochemical failure was also higher in group A and C (P = 0.001). However, the groups were not independent factors in multivariate analysis. In conclusion, large difference between bGS and pGS shows poor prognosis even in the decreased group. However it is not an independent prognostic factor for biochemical failure.
Files in This Item:
T201100942.pdf Download
DOI
10.3346/jkms.2011.26.4.507
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Urology (비뇨의학교실) > 1. Journal Papers
Yonsei Authors
Chung, Byung Ha(정병하) ORCID logo https://orcid.org/0000-0001-9817-3660
Choi, Young Deuk(최영득) ORCID logo https://orcid.org/0000-0002-8545-5797
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/92861
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