50 131

Cited 4 times in

Clinical significance of a large difference (≥ 2 points) between biopsy and post-prostatectomy pathological Gleason scores in patients with prostate cancer.

 Changhee Yoo  ;  Cheol Young Oh  ;  Han Yong Choi  ;  Seok-Soo Byun  ;  Wun-Jae Kim  ;  Hyung Jin Kim  ;  Byung Ha Chung  ;  Young Deuk Choi  ;  Eun Sik Lee  ;  Hyun Moo Lee  ;  Sang Eun Lee  ;  Moon Kee Chung  ;  Tae Young Jung  ;  Tae Gyun Kwon  ;  Kang Hyun Lee  ;  Jun Cheon  ;  Tae-Kon Hwang  ;  Hanjong Ahn  ;  Seong Il Seo  ;  Cheryn Song  ;  Jin Seon Cho 
 Journal of Korean Medical Science, Vol.26(4) : 507-512, 2011 
Journal Title
 Journal of Korean Medical Science 
Issue Date
We investigated the clinical significance of large difference (≥ 2 points) between biopsy-derived (bGS) and post-prostatectomy Gleason scores (pGS). At 14 medical centers in Korea, 1,582 men who underwent radical prostatectomy for prostate cancer were included. According to the difference between bGS and pGS, the patients were divided into three groups: A (decreased in pGS ≥ 2, n = 30), B (changed in pGS ≤ 1, n = 1,361; control group), and C (increased in pGS ≥ 2, n = 55). We evaluated various clinicopathological factors of prostate cancer and hazards for biochemical failure. Group A showed significantly higher mean maximal percentage of cancer in the positive cores (max%) and pathological T stage than control. In group C, the number of biopsy core was significantly smaller, however, tumor volume and max% were significantly higher and more positive biopsy cores were presented than control. Worse pathological stage and more margin-positive were observed in group A and C than in control. Hazard ratio for biochemical failure was also higher in group A and C (P = 0.001). However, the groups were not independent factors in multivariate analysis. In conclusion, large difference between bGS and pGS shows poor prognosis even in the decreased group. However it is not an independent prognostic factor for biochemical failure.
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Urology (비뇨의학교실)
Yonsei Authors
정병하(Chung, Byung Ha) ; 최영득(Choi, Young Deuk)
사서에게 알리기
Files in This Item:
T201100942.pdf Download
RIS (EndNote)
XLS (Excel)


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.