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Radiosurgery for radiosurgery-induced cavernous malformation

 Young Seok Park  ;  Se Hoon Kim  ;  Jong Hee Chang  ;  Jin Woo Chang  ;  Yong Gou Park 
 WORLD NEUROSURGERY, Vol.75(1) : 94-98, 2011 
Journal Title
Issue Date
Brain Stem Neoplasms/etiology ; Brain Stem Neoplasms/pathology ; Brain Stem Neoplasms/surgery* ; Female ; Hemangioma, Cavernous, Central Nervous System/etiology ; Hemangioma, Cavernous, Central Nervous System/pathology ; Hemangioma, Cavernous, Central Nervous System/surgery* ; Humans ; Neoplasms, Radiation-Induced/etiology ; Neoplasms, Radiation-Induced/pathology ; Neoplasms, Radiation-Induced/surgery* ; Pinealoma/pathology ; Pinealoma/surgery* ; Radiosurgery/adverse effects* ; Radiosurgery/methods* ; Young Adult
Cavernous malformation ; Gamma knife surgery ; Radiosurgery
BACKGROUND: This report describes the use of radiosurgery for the treatment of a radiosurgery-induced cavernous malformation (CM).

METHODS: A 21-year-old woman underwent stereotactic biopsy of a pineocytoma and subsequent gamma knife radiosurgery (marginal 14.5 Gy, 50%) for the lesion. A T1-weighted enhanced magnetic resonance imaging one year later showed that the tumor had disappeared. After two years, she developed facial palsy and experienced mental status changes. It was found that she experienced repeated hemorrhages in that radiation field, and magnetic resonance imaging showed a CM.

RESULTS: The area where the CM developed had been exposed to 5.0 ± 3.7 Gy. This value was calculated using the fused dose planning image using Leksell GammaPlan. We used gamma knife radiosurgery to treat this lesion (marginal 12.5 Gy, 50%), and believe that it is a radiation-induced CM. Five years after gamma knife radiosurgery for the CM, the CM has controlled without any new hemorrhages.

CONCLUSIONS: Gamma knife radiosurgery-induced CMs are very rare, and the use of another gamma knife radiosurgery to treat this lesion has not yet been reported. We report a case of radiosurgery for CM that was induced by gamma knife radiosurgery for a pineocytoma. This report suggests that radiosurgery is a reasonable option for treating radiation-induced CM to prevent repeated hemorrhage
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1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
Kim, Se Hoon(김세훈) ORCID logo https://orcid.org/0000-0001-7516-7372
Park, Yong Gou(박용구)
Chang, Jong Hee(장종희) ORCID logo https://orcid.org/0000-0003-1509-9800
Chang, Jin Woo(장진우) ORCID logo https://orcid.org/0000-0002-2717-0101
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