Cited 54 times in
Effects of coenzyme Q10 on arterial stiffness, metabolic parameters, and fatigue in obese subjects: a double-blind randomized controlled study
DC Field | Value | Language |
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dc.contributor.author | 이덕철 | - |
dc.contributor.author | 이용제 | - |
dc.date.accessioned | 2014-12-20T16:28:55Z | - |
dc.date.available | 2014-12-20T16:28:55Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 1096-620X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/92797 | - |
dc.description.abstract | This study investigated the effects of coenzyme Q(10) supplementation on metabolic parameters, inflammatory markers, arterial stiffness, and fatigue in obese subjects. We performed a randomized, double-blind, placebo-controlled, single-center study on 51 obese subjects with a body mass index (BMI) of ≥25 kg/m(2). Subjects were randomized into either a coenzyme Q(10) (200 mg/day) group (n = 26, BMI = 27.9 ± 2.3 kg/m(2), age = 42.7 ± 11.3 years) or a placebo group (n = 25, BMI = 26.8 ± 2.8 kg/m(2), age = 41.3 ± 11.2 years) for a 12-week study. We collected anthropometric measurements, blood for laboratory testing, brachial-ankle pulse wave velocity (baPWV) as an indicator of arterial stiffness, and responses to a fatigue severity scale (FSS) questionnaire at the initial (0 week) and final (12 weeks) visits. A total of 36 subjects successfully completed the study protocol. Serum coenzyme Q(10) levels increased significantly from 0.65 ± 0.27 μg/mL to 1.20 ± 0.38 μg/mL in the coenzyme Q(10) group (P < .001). Oral administration of coenzyme Q(10) did not significantly affect lipid profiles, oxidative and inflammatory markers [including lipoprotein (a), oxidized low-density lipoprotein level, C-reactive protein, and white blood cell count], or baPWV. The mean FSS score decreased significantly from 40.1 to 33.1 in the coenzyme Q(10) group (P = .017), but no significant change was seen in the placebo group (P = .464). However, the extents of the change in mean FSS score between the placebo and coenzyme Q(10) groups were not significantly different (P = .287). In conclusion, we found no evidence that coenzyme Q(10) affects fatigue index, arterial stiffness, metabolic parameters, or inflammatory markers. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | JOURNAL OF MEDICINAL FOOD | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Administration, Oral | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Ankle Brachial Index | - |
dc.subject.MESH | Arteries/physiopathology* | - |
dc.subject.MESH | Blood Glucose/analysis | - |
dc.subject.MESH | Body Mass Index | - |
dc.subject.MESH | C-Reactive Protein/analysis | - |
dc.subject.MESH | Cholesterol, LDL/blood | - |
dc.subject.MESH | Double-Blind Method | - |
dc.subject.MESH | Fatigue/drug therapy* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Obesity/physiopathology* | - |
dc.subject.MESH | Surveys and Questionnaires | - |
dc.subject.MESH | Ubiquinone/analogs & derivatives* | - |
dc.subject.MESH | Ubiquinone/pharmacology | - |
dc.subject.MESH | Vascular Resistance/drug effects* | - |
dc.title | Effects of coenzyme Q10 on arterial stiffness, metabolic parameters, and fatigue in obese subjects: a double-blind randomized controlled study | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Family Medicine (가정의학) | - |
dc.contributor.googleauthor | Yong-Jae Lee | - |
dc.contributor.googleauthor | Wan-Je Cho | - |
dc.contributor.googleauthor | Jong-Koo Kim | - |
dc.contributor.googleauthor | Duk-Chul Lee | - |
dc.identifier.doi | 10.1089/jmf.2010.1202 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00915 | - |
dc.contributor.localId | A02716 | - |
dc.contributor.localId | A02982 | - |
dc.relation.journalcode | J01589 | - |
dc.identifier.eissn | 1557-7600 | - |
dc.identifier.pmid | 21370966 | - |
dc.identifier.url | http://online.liebertpub.com/doi/abs/10.1089/jmf.2010.1202 | - |
dc.subject.keyword | coenzyme Q10 | - |
dc.subject.keyword | fatigue | - |
dc.subject.keyword | obesity | - |
dc.subject.keyword | randomized clinical trial | - |
dc.contributor.alternativeName | Kim, Jong Koo | - |
dc.contributor.alternativeName | Lee, Duk Chul | - |
dc.contributor.alternativeName | Lee, Yong Jae | - |
dc.contributor.affiliatedAuthor | Kim, Jong Koo | - |
dc.contributor.affiliatedAuthor | Lee, Duk Chul | - |
dc.contributor.affiliatedAuthor | Lee, Yong Jae | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 14 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 386 | - |
dc.citation.endPage | 390 | - |
dc.identifier.bibliographicCitation | JOURNAL OF MEDICINAL FOOD, Vol.14(4) : 386-390, 2011 | - |
dc.identifier.rimsid | 28762 | - |
dc.type.rims | ART | - |
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