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Effects of coenzyme Q10 on arterial stiffness, metabolic parameters, and fatigue in obese subjects: a double-blind randomized controlled study

DC FieldValueLanguage
dc.contributor.author김종구-
dc.contributor.author이덕철-
dc.contributor.author이용제-
dc.date.accessioned2014-12-20T16:28:55Z-
dc.date.available2014-12-20T16:28:55Z-
dc.date.issued2011-
dc.identifier.issn1096-620X-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/92797-
dc.description.abstractThis study investigated the effects of coenzyme Q(10) supplementation on metabolic parameters, inflammatory markers, arterial stiffness, and fatigue in obese subjects. We performed a randomized, double-blind, placebo-controlled, single-center study on 51 obese subjects with a body mass index (BMI) of ≥25 kg/m(2). Subjects were randomized into either a coenzyme Q(10) (200 mg/day) group (n = 26, BMI = 27.9 ± 2.3 kg/m(2), age = 42.7 ± 11.3 years) or a placebo group (n = 25, BMI = 26.8 ± 2.8 kg/m(2), age = 41.3 ± 11.2 years) for a 12-week study. We collected anthropometric measurements, blood for laboratory testing, brachial-ankle pulse wave velocity (baPWV) as an indicator of arterial stiffness, and responses to a fatigue severity scale (FSS) questionnaire at the initial (0 week) and final (12 weeks) visits. A total of 36 subjects successfully completed the study protocol. Serum coenzyme Q(10) levels increased significantly from 0.65 ± 0.27 μg/mL to 1.20 ± 0.38 μg/mL in the coenzyme Q(10) group (P < .001). Oral administration of coenzyme Q(10) did not significantly affect lipid profiles, oxidative and inflammatory markers [including lipoprotein (a), oxidized low-density lipoprotein level, C-reactive protein, and white blood cell count], or baPWV. The mean FSS score decreased significantly from 40.1 to 33.1 in the coenzyme Q(10) group (P = .017), but no significant change was seen in the placebo group (P = .464). However, the extents of the change in mean FSS score between the placebo and coenzyme Q(10) groups were not significantly different (P = .287). In conclusion, we found no evidence that coenzyme Q(10) affects fatigue index, arterial stiffness, metabolic parameters, or inflammatory markers.-
dc.description.statementOfResponsibilityopen-
dc.format.extent386~390-
dc.relation.isPartOfJournal of Medicinal Food-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdministration, Oral-
dc.subject.MESHAdult-
dc.subject.MESHAnkle Brachial Index-
dc.subject.MESHArteries/physiopathology*-
dc.subject.MESHBlood Glucose/analysis-
dc.subject.MESHBody Mass Index-
dc.subject.MESHC-Reactive Protein/analysis-
dc.subject.MESHCholesterol, LDL/blood-
dc.subject.MESHDouble-Blind Method-
dc.subject.MESHFatigue/drug therapy*-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHObesity/physiopathology*-
dc.subject.MESHSurveys and Questionnaires-
dc.subject.MESHUbiquinone/analogs & derivatives*-
dc.subject.MESHUbiquinone/pharmacology-
dc.subject.MESHVascular Resistance/drug effects*-
dc.titleEffects of coenzyme Q10 on arterial stiffness, metabolic parameters, and fatigue in obese subjects: a double-blind randomized controlled study-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Family Medicine (가정의학)-
dc.contributor.googleauthorYong-Jae Lee-
dc.contributor.googleauthorWan-Je Cho-
dc.contributor.googleauthorJong-Koo Kim-
dc.contributor.googleauthorDuk-Chul Lee-
dc.identifier.doi10.1089/jmf.2010.1202-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00915-
dc.contributor.localIdA02716-
dc.contributor.localIdA02982-
dc.relation.journalcodeJ01589-
dc.identifier.pmid21370966-
dc.identifier.urlhttp://online.liebertpub.com/doi/abs/10.1089/jmf.2010.1202-
dc.subject.keywordcoenzyme Q10-
dc.subject.keywordfatigue-
dc.subject.keywordobesity-
dc.subject.keywordrandomized clinical trial-
dc.contributor.alternativeNameKim, Jong Koo-
dc.contributor.alternativeNameLee, Duk Chul-
dc.contributor.alternativeNameLee, Yong Jae-
dc.contributor.affiliatedAuthorKim, Jong Koo-
dc.contributor.affiliatedAuthorLee, Duk Chul-
dc.contributor.affiliatedAuthorLee, Yong Jae-
dc.rights.accessRightsnot free-
dc.citation.volume14-
dc.citation.number4-
dc.citation.startPage386-
dc.citation.endPage390-
dc.identifier.bibliographicCitationJournal of Medicinal Food, Vol.14(4) : 386-390, 2011-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Family Medicine (가정의학교실) > 1. Journal Papers

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