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Enhancing effect of pretreatment with topical niacin in the treatment of rosacea-associated erythema by 585-nm pulsed dye laser in Koreans: a randomized, prospective, split-face trial

 T.G. Kim  ;  H.J. Roh  ;  S.B. Cho  ;  J.H. Lee  ;  S.J. Lee  ;  S.H. Oh 
 BRITISH JOURNAL OF DERMATOLOGY, Vol.164(3) : 573-579, 2011 
Journal Title
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Adult ; Asian Continental Ancestry Group ; Erythema/drug therapy* ; Erythema/etiology ; Erythema/radiotherapy* ; Female ; Humans ; Korea ; Low-Level Light Therapy* ; Male ; Middle Aged ; Niacin/therapeutic use* ; Patient Satisfaction ; Photochemotherapy/methods* ; Prospective Studies ; Rosacea/complications* ; Vasodilator Agents/therapeutic use*
BACKGROUND: Rosacea is a chronic dermatosis that is usually confined to the face. A pulsed dye laser (PDL) system has been proven to be effective in treating rosacea-associated erythema and telangiectasias. Niacin is a cutaneous vasodilator that can increase the chromophore through increased blood flow. OBJECTIVES: We hypothesized that increased blood flow by pretreatment with topical niacin could enhance the effect of PDL in the treatment of rosacea. METHODS: Eighteen Korean patients with rosacea were recruited. Three sessions of 585-nm PDL using a subpurpuragenic dose with and without pretreatment with niacin cream were performed on randomly assigned half-faces at 3-week intervals. Erythema was assessed objectively by a polarization colour imaging system, and evaluations were also made by three blinded dermatologists. Patient satisfaction was evaluated using a 10-point visual analogue scale. RESULTS: Fifteen patients completed this study. All patients showed an improvement in erythema after three sessions of PDL treatment both with and without niacin pretreatment (P = 0·023 and P = 0·009, respectively). There was no significant difference in the improvement of objective erythema between the two sides. However, based on physician assessment the overall clinical improvement on the niacin side was significantly higher (P = 0·005), and patient satisfaction was also higher on the niacin-pretreated side (P = 0·007). There were no remarkable side-effects, with the exception of transient erythema and oedema. CONCLUSIONS: Pretreatment with topical niacin safely enhanced the effect of 585-nm PDL treatment of rosacea-associated erythema in Koreans. Application of niacin can be helpful in overcoming the relatively lower effect of subpurpuragenic PDL in dark-skinned Asians.
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1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실) > 1. Journal Papers
Yonsei Authors
Roh, Hyo Jin(노효진)
Oh, Sang Ho(오상호) ORCID logo https://orcid.org/0000-0002-4477-1400
Lee, Ju Hee(이주희) ORCID logo https://orcid.org/0000-0002-1739-5956
Cho, Sung Bin(조성빈)
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