1 214

Cited 104 times in

The pattern of cortical atrophy in patients with Parkinson's disease according to cognitive status

 Sook K. Song  ;  Ji E. Lee  ;  Hae-Jeong Park  ;  Young H. Sohn  ;  Jong Doo Lee  ;  Phil Hyu Lee 
 MOVEMENT DISORDERS, Vol.26(2) : 289-296, 2011 
Journal Title
Issue Date
Atrophy/pathology ; Atrophy/psychology ; Cerebral Cortex/pathology* ; Cognition/physiology* ; Humans ; Image Processing, Computer-Assisted ; Magnetic Resonance Imaging ; Male ; Nerve Fibers, Unmyelinated/pathology* ; Neurons/pathology ; Neuropsychological Tests ; Parkinson Disease/pathology* ; Parkinson Disease/psychology ; Prospective Studies ; Statistics, Nonparametric
Parkinson’s disease ; mild cognitive impairment ; dementia ; cortical atrophy
BACKGROUND: Cognitive dysfunction is common in Parkinson's disease (PD), and along with PD with dementia (PDD), the concept of mild cognitive impairment in PD (PD-MCI) has been introduced. METHODS: To identify structural candidates according to cognitive status in PD, we compared gray matter (GM) density across PD-intact cognition (PD-IC, n = 23), PD-MCI (n = 27), and PDD (n = 18) using voxel-based morphometry. RESULTS: The demographic data among PD subjects were similar, however, general cognition and disease duration were more severe in PD-MCI and PDD than in PD-IC. Compared with controls, GM density was significantly decreased in the left occipital area in PD-IC; the bilateral temporal, left prefrontal and insular, and right occipital areas in PD-MCI; and in widespread brain areas in PDD. Compared with PD-IC, patients with PD-MCI had significantly decreased GM density in the right middle frontal area, and those with PDD had decreased GM density in the right parietal, middle frontal, insular, and lentiform areas. GM density in patients with PDD was significantly decreased in the bilateral middle temporal, right inferior temporal, and left middle and superior prefrontal areas. PDD patients with shorter disease duration before dementia (<5 year) showed greater GM atrophy in the posterior cingulate area than did those with longer disease duration (≥5 year). CONCLUSIONS: These data suggest that cortical atrophy in PD exhibits a greater extent with increasing levels of cognitive impairment, and different anatomical substrates would correspond to each cognitive status.
Full Text
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers
Yonsei Authors
Park, Hae Jeong(박해정) ORCID logo https://orcid.org/0000-0002-4633-0756
Sohn, Young Ho(손영호) ORCID logo https://orcid.org/0000-0001-6533-2610
Lee, Jong Doo(이종두)
Lee, Ji Eun(이지은)
Lee, Phil Hyu(이필휴) ORCID logo https://orcid.org/0000-0001-9931-8462
사서에게 알리기


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.