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Loss of E-cadherin and MUC2 expressions correlated with poor survival in patients with stages II and III colorectal carcinoma

 Haeyoun Kang  ;  Byung Soh Min  ;  Kang Young Lee  ;  Nam Kyu Kim  ;  Soo Nyung Kim  ;  Junjeong Choi  ;  Hoguen Kim 
 ANNALS OF SURGICAL ONCOLOGY, Vol.18(3) : 711-719, 2011 
Journal Title
Issue Date
Adenocarcinoma/metabolism* ; Adenocarcinoma/mortality* ; Adenocarcinoma/therapy ; Aged ; Biomarkers, Tumor/metabolism ; Cadherins/metabolism* ; Colorectal Neoplasms/metabolism* ; Colorectal Neoplasms/mortality* ; Colorectal Neoplasms/therapy ; Female ; Humans ; Immunoenzyme Techniques ; Male ; Mucin-2/metabolism* ; Neoplasm Staging ; Prognosis ; Survival Rate ; Tissue Array Analysis
Colorectal Carcinoma ; Lymphovascular Invasion ; Perineural Invasion ; Postoperative Adjuvant Therapy ; pTNM Stage
BACKGROUND: With the recent development of molecular markers, it has become possible to characterize colorectal carcinomas beyond clinical and histologic aspects. When considered together with tumor stage, molecular markers will allow us further insight into individual tumor biologies and prognoses. PURPOSE: To investigate the expression and prognostic implications of the molecular markers, p53, bcl-2, Rb, hMLH1, hMSH2, β-catenin, E-cadherin, and MUC-2. METHODS: We analyzed the clinical, histologic, and molecular factors for 229 patients with colorectal carcinoma of stage II and III and compared their prognoses. We used tissue microarrays to analyze the expressions of molecular markers and to assess their correlations with prognosis. Semiquantitative expressions of molecular markers and clinicopathologic parameters were analyzed with respect to prognosis. RESULTS: Among the clinicopathologic parameters, left-sided location, age older than 70 years, higher preoperative serum carcinoembryonic antigen (CEA) level (≤ 5 ng/mL), irregular growth pattern, and perineural invasion were significantly related to poor prognosis in stage II and III patients. For molecular factors, loss of expression of E-cadherin and MUC-2 showed significant correlation with poor overall survival in both cancer stages. Multivariate analysis showed that higher TNM stage, higher preoperative serum CEA level (≤ 5 ng/mL), perineural tumor cell invasion, and loss of E-cadherin and MUC-2 expressions were independently correlated with poor overall survival. CONCLUSIONS: Our results indicated that of the analyzed molecular markers, MUC-2 and E-cadherin might be useful in predicting prognosis and planning for adjuvant therapy in patients with stage II and III colorectal carcinomas.
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1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Nam Kyu(김남규) ORCID logo https://orcid.org/0000-0003-0639-5632
Kim, Ho Keun(김호근)
Min, Byung Soh(민병소) ORCID logo https://orcid.org/0000-0003-0180-8565
Lee, Kang Young(이강영)
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