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The effect of combining dexamethasone with ondansetron for nausea and vomiting associated with fentanyl-based intravenous patient-controlled analgesia.

 J. W. Song  ;  E. Y. Park  ;  J. G. Lee  ;  Y. S. Park  ;  B. C. Kang  ;  Y. H. Shim 
 ANAESTHESIA, Vol.66(4) : 263-267, 2011 
Journal Title
Issue Date
Adult ; Aged ; Analgesia, Patient-Controlled/adverse effects* ; Analgesics, Opioid/administration & dosage ; Analgesics, Opioid/adverse effects ; Antiemetics/therapeutic use* ; Dexamethasone/therapeutic use* ; Drug Therapy, Combination ; Female ; Fentanyl/administration & dosage ; Fentanyl/adverse effects ; Humans ; Male ; Middle Aged ; Ondansetron/therapeutic use* ; Pain, Postoperative/prevention & control ; Postoperative Nausea and Vomiting/chemically induced ; Postoperative Nausea and Vomiting/prevention & control* ; Severity of Illness Index ; Thoracic Surgery, Video-Assisted ; Treatment Outcome ; Young Adult
We investigated whether combined dexamethasone and ondansetron is more effective than ondansetron alone in preventing postoperative nausea and vomiting in patients with fentanyl-based intravenous patient-controlled analgesia. One hundred and thirty patients undergoing video-assisted thoracoscopic surgery were assigned to either an ondansetron group or a dexamethasone and ondansetron group. In all patients, ondansetron 4 mg was administered at the end of surgery and 12 mg was added to the patient-controlled analgesia solution. The dexamethasone and ondansetron group received dexamethasone 8 mg at the induction of anaesthesia. The overall incidence of nausea and vomiting during the first 48 h postoperatively did not differ between groups (34/61 (56%) vs 28/62 (45%) in the ondansetron group and dexamethasone and ondansetron groups, respectively). The incidence of severe nausea and vomiting (≥ 7 nausea on an 11-point verbal numerical rating scale, retching or vomiting) was higher in the ondansetron group than in the dexamethasone and ondansetron group (15/61 (25%) vs 6/62 (10%, respectively, p=0.028). Combined dexamethasone and ondansetron is more effective in reducing severe nausea and vomiting than ondansetron alone in patients receiving fentanyl-based intravenous patient-controlled analgesia.
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1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Thoracic and Cardiovascular Surgery (흉부외과학교실) > 1. Journal Papers
Yonsei Authors
Park, Y. S.(박연수)
Song, Jong Wook(송종욱) ORCID logo https://orcid.org/0000-0001-7518-2070
Shim, Yon Hee(심연희) ORCID logo https://orcid.org/0000-0003-1921-3391
Lee, Jin Gu(이진구)
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