3 206

Cited 99 times in

Sex differences in central hemodynamics and their relationship to left ventricular diastolic function

Authors
 Chi Young Shim  ;  Sungha Park  ;  Donghoon Choi  ;  Woo-In Yang  ;  In-Jeong Cho  ;  Eui-Young Choi  ;  Namsik Chung  ;  Jong-Won Ha 
Citation
 JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol.57(10) : 1226-1233, 2011 
Journal Title
 JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY 
ISSN
 0735-1097 
Issue Date
2011
MeSH
Aged ; Arteries/pathology ; Blood Pressure/physiology ; Echocardiography, Doppler ; Elasticity ; Elasticity Imaging Techniques ; Female ; Heart Failure/physiopathology ; Hemodynamics ; Humans ; Male ; Manometry ; Middle Aged ; Radial Artery/physiopathology ; Sex Factors ; Stroke Volume/physiology ; Ventricular Dysfunction, Left/epidemiology* ; Ventricular Dysfunction, Left/physiopathology*
Keywords
arterial stiffness ; diastolic function ; left ventricle ; sex
Abstract
OBJECTIVES: This study aimed to investigate sex differences in the association between arterial stiffness and left ventricular (LV) diastolic dysfunction. BACKGROUND: Heart failure with preserved ejection fraction is more common in women. Arterial stiffness has been suggested as a significant contributor to the development of heart failure. We hypothesized that the association between arterial stiffness and LV diastolic function would be stronger in women than in men. METHODS: Two-dimensional, Doppler echocardiography and radial artery tonometry were performed simultaneously in 158 age-matched subjects (79 males, 79 females; mean age: 58 ± 10 years) without any structural heart disease or LV systolic dysfunction. RESULTS: The peripheral blood pressure and pulse pressure (PP) were similar between sexes. However, central PP and augmentation index were significantly higher and PP amplification was significantly lower in women (1.31 vs. 1.19, p < 0.001). The associations of PP amplification with early diastolic mitral annular (Em) velocity and transmitral to mitral annular early diastolic velocity ratio (E/Em) were significant in women (r = 0.38, p = 0.001; r = -0.36, p = 0.001), whereas no significant association was found in men (r = 0.09, p = 0.428, r = -0.14, p = 0.215). Multiple regression analysis revealed that PP amplification had an independent correlation with Em velocity only in women. CONCLUSIONS: Despite similar peripheral PP, the central hemodynamics reflecting arterial stiffness were different between men and women. LV diastolic function correlates significantly with the parameters representing arterial stiffness only in women. We suggest that the effects of earlier wave reflection on central pressure may contribute to greater susceptibility to heart failure with preserved LV ejection fraction in women.
Full Text
http://www.sciencedirect.com/science/article/pii/S0735109710049648
DOI
10.1016/j.jacc.2010.09.067
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Park, Sung Ha(박성하) ORCID logo https://orcid.org/0000-0001-5362-478X
Shim, Chi Young(심지영) ORCID logo https://orcid.org/0000-0002-6136-0136
Yang, Woo In(양우인)
Chung, Nam Sik(정남식)
Cho, In Jeong(조인정)
Choi, Dong Hoon(최동훈) ORCID logo https://orcid.org/0000-0002-2009-9760
Choi, Eui Young(최의영) ORCID logo https://orcid.org/0000-0003-3732-0190
Ha, Jong Won(하종원) ORCID logo https://orcid.org/0000-0002-8260-2958
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/92726
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse