Cited 47 times in
Identification of genes associated with chemosensitivity to SAHA/taxane combination treatment in taxane-resistant breast cancer cells
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 라선영 | - |
dc.contributor.author | 장현 | - |
dc.contributor.author | 정재준 | - |
dc.contributor.author | 정현철 | - |
dc.contributor.author | 정희철 | - |
dc.date.accessioned | 2014-12-20T16:26:00Z | - |
dc.date.available | 2014-12-20T16:26:00Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 0167-6806 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/92706 | - |
dc.description.abstract | Here we evaluated the cytotoxic effects of a combination of the histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA) and taxanes in human breast cancer cell lines. Combination treatment with taxane and SAHA had a synergistic cytotoxic effect against taxane-resistant breast cancer cells. Oligonucleotide microarray analysis identified 28 genes (MAPK13, ATP2C1, ANKRD57, MT1G, RGL4, C12orf49, EXOC6, RAB4A, TM9SF3, IFNGR1, DMD, HCG9, KIFC3, SYNGR3, NDRG4, NT5E, EOMES, SMC4, LANCL1, SCHIP1, and 8 ESTs) whose expression correlated with the combined effect of paclitaxel and SAHA. Twelve of these genes were down-regulated in cell lines that were paclitaxel-resistant but combination synergistic. SAHA induced NT5E mRNA expression in paclitaxel-resistant YCC-B1 cell. Our results indicate that a combination of taxane and SAHA could be efficacious for the treatment of breast cancer and that genes involved in the synergistic response to paclitaxel and SAHA could serve as biomarkers to predict therapeutic response in breast cancer patients. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 55~63 | - |
dc.relation.isPartOf | BREAST CANCER RESEARCH AND TREATMENT | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Antineoplastic Agents, Phytogenic/pharmacology | - |
dc.subject.MESH | Antineoplastic Combined Chemotherapy Protocols/pharmacology* | - |
dc.subject.MESH | BreastNeoplasms/genetics* | - |
dc.subject.MESH | BreastNeoplasms/pathology | - |
dc.subject.MESH | Cell Proliferation/drug effects | - |
dc.subject.MESH | Dose-Response Relationship, Drug | - |
dc.subject.MESH | Drug Resistance, Neoplasm/genetics* | - |
dc.subject.MESH | Drug Synergism | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Gene Expression Profiling*/methods | - |
dc.subject.MESH | Gene Expression Regulation, Neoplastic | - |
dc.subject.MESH | Histone Deacetylase Inhibitors/pharmacology | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Hydroxamic Acids/pharmacology | - |
dc.subject.MESH | Inhibitory Concentration 50 | - |
dc.subject.MESH | Oligonucleotide Array Sequence Analysis | - |
dc.subject.MESH | Paclitaxel/pharmacology | - |
dc.subject.MESH | RNA, Messenger/metabolism | - |
dc.subject.MESH | Reproducibility of Results | - |
dc.subject.MESH | Reverse Transcriptase Polymerase Chain Reaction | - |
dc.title | Identification of genes associated with chemosensitivity to SAHA/taxane combination treatment in taxane-resistant breast cancer cells | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Medical Research Center (임상의학연구센터) | - |
dc.contributor.googleauthor | Hyun Chang | - |
dc.contributor.googleauthor | Hei-Cheul Jeung | - |
dc.contributor.googleauthor | Je Jun Jung | - |
dc.contributor.googleauthor | Tae Soo Kim | - |
dc.contributor.googleauthor | Sun Young Rha | - |
dc.contributor.googleauthor | Hyun Cheol Chung | - |
dc.identifier.doi | 10.1007/s10549-010-0825-z | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A03491 | - |
dc.contributor.localId | A03773 | - |
dc.contributor.localId | A03794 | - |
dc.contributor.localId | A01316 | - |
dc.relation.journalcode | J00403 | - |
dc.identifier.eissn | 1573-7217 | - |
dc.identifier.pmid | 20224928 | - |
dc.identifier.url | http://link.springer.com/article/10.1007%2Fs10549-010-0825-z | - |
dc.subject.keyword | Suberoylanilide hydroxamic acid | - |
dc.subject.keyword | Taxane resistance | - |
dc.subject.keyword | Combination chemotherapy | - |
dc.subject.keyword | Chemosensitivity | - |
dc.subject.keyword | Breast neoplasms | - |
dc.subject.keyword | Expression profiling | - |
dc.contributor.alternativeName | Rha, Sun Young | - |
dc.contributor.alternativeName | Chang, Hyun | - |
dc.contributor.alternativeName | Jung, Jae Joon | - |
dc.contributor.alternativeName | Chung, Hyun Cheol | - |
dc.contributor.alternativeName | Jeung, Hei Cheul | - |
dc.contributor.affiliatedAuthor | Chang, Hyun | - |
dc.contributor.affiliatedAuthor | Chung, Hyun Cheol | - |
dc.contributor.affiliatedAuthor | Jeung, Hei Cheul | - |
dc.contributor.affiliatedAuthor | Rha, Sun Young | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 125 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 55 | - |
dc.citation.endPage | 63 | - |
dc.identifier.bibliographicCitation | BREAST CANCER RESEARCH AND TREATMENT, Vol.125(1) : 55-63, 2011 | - |
dc.identifier.rimsid | 28708 | - |
dc.type.rims | ART | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.