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Transient retinoic acid signaling confers anterior-posterior polarity to the inner ear

DC FieldValueLanguage
dc.contributor.author공경아-
dc.contributor.author복진웅-
dc.date.accessioned2014-12-20T16:25:46Z-
dc.date.available2014-12-20T16:25:46Z-
dc.date.issued2011-
dc.identifier.issn0027-8424-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/92699-
dc.description.abstractVertebrate hearing and balance are based in complex asymmetries of inner ear structure. Here, we identify retinoic acid (RA) as an extrinsic signal that acts directly on the ear rudiment to affect its compartmentalization along the anterior-posterior axis. A rostrocaudal wave of RA activity, generated by tissues surrounding the nascent ear, induces distinct responses from anterior and posterior halves of the inner ear rudiment. Prolonged response to RA by posterior otic tissue correlates with Tbx1 transcription and formation of mostly nonsensory inner ear structures. By contrast, anterior otic tissue displays only a brief response to RA and forms neuronal elements and most sensory structures of the inner ear-
dc.description.statementOfResponsibilityopen-
dc.format.extent161~166-
dc.relation.isPartOfProceedings of the National Academy of Sciences of the United States of America-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAnimals-
dc.subject.MESHBody Patterning/physiology*-
dc.subject.MESHChick Embryo-
dc.subject.MESHCycloheximide-
dc.subject.MESHEar, Inner/embryology*-
dc.subject.MESHGene Expression Regulation, Developmental/genetics-
dc.subject.MESHGene Expression Regulation, Developmental/physiology*-
dc.subject.MESHIn Situ Hybridization-
dc.subject.MESHMice-
dc.subject.MESHMicrospheres-
dc.subject.MESHSignal Transduction/physiology*-
dc.subject.MESHT-Box Domain Proteins/metabolism*-
dc.subject.MESHTretinoin/metabolism*-
dc.subject.MESHbeta-Galactosidase-
dc.titleTransient retinoic acid signaling confers anterior-posterior polarity to the inner ear-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Anatomy (해부학)-
dc.contributor.googleauthorJinwoong Bok-
dc.contributor.googleauthorSteven Raft-
dc.contributor.googleauthorKyoung-Ah Kong-
dc.contributor.googleauthorSoo Kyung Koo-
dc.contributor.googleauthorUrsula C. Dräger-
dc.contributor.googleauthorDoris K. Wu-
dc.identifier.doi10.1073/pnas.1010547108-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00158-
dc.contributor.localIdA01865-
dc.relation.journalcodeJ02550-
dc.identifier.pmid21173260-
dc.subject.keywordaxial specification-
dc.subject.keyworddevelopmental compartments-
dc.subject.keywordmorphogen-
dc.contributor.alternativeNameKong, Kyoung Ah-
dc.contributor.alternativeNameBok, Jin Woong-
dc.contributor.affiliatedAuthorKong, Kyoung Ah-
dc.contributor.affiliatedAuthorBok, Jin Woong-
dc.rights.accessRightsfree-
dc.citation.volume108-
dc.citation.number1-
dc.citation.startPage161-
dc.citation.endPage166-
dc.identifier.bibliographicCitationProceedings of the National Academy of Sciences of the United States of America, Vol.108(1) : 161-166, 2011-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anatomy (해부학교실) > 1. Journal Papers

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