Cited 77 times in
Transient retinoic acid signaling confers anterior-posterior polarity to the inner ear
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 공경아 | - |
dc.contributor.author | 복진웅 | - |
dc.date.accessioned | 2014-12-20T16:25:46Z | - |
dc.date.available | 2014-12-20T16:25:46Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 0027-8424 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/92699 | - |
dc.description.abstract | Vertebrate hearing and balance are based in complex asymmetries of inner ear structure. Here, we identify retinoic acid (RA) as an extrinsic signal that acts directly on the ear rudiment to affect its compartmentalization along the anterior-posterior axis. A rostrocaudal wave of RA activity, generated by tissues surrounding the nascent ear, induces distinct responses from anterior and posterior halves of the inner ear rudiment. Prolonged response to RA by posterior otic tissue correlates with Tbx1 transcription and formation of mostly nonsensory inner ear structures. By contrast, anterior otic tissue displays only a brief response to RA and forms neuronal elements and most sensory structures of the inner ear | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 161~166 | - |
dc.relation.isPartOf | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Body Patterning/physiology* | - |
dc.subject.MESH | Chick Embryo | - |
dc.subject.MESH | Cycloheximide | - |
dc.subject.MESH | Ear,Inner/embryology* | - |
dc.subject.MESH | Gene Expression Regulation, Developmental/genetics | - |
dc.subject.MESH | Gene Expression Regulation, Developmental/physiology* | - |
dc.subject.MESH | In Situ Hybridization | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Microspheres | - |
dc.subject.MESH | Signal Transduction/physiology* | - |
dc.subject.MESH | T-Box Domain Proteins/metabolism* | - |
dc.subject.MESH | Tretinoin/metabolism* | - |
dc.subject.MESH | beta-Galactosidase | - |
dc.title | Transient retinoic acid signaling confers anterior-posterior polarity to the inner ear | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Anatomy (해부학) | - |
dc.contributor.googleauthor | Jinwoong Bok | - |
dc.contributor.googleauthor | Steven Raft | - |
dc.contributor.googleauthor | Kyoung-Ah Kong | - |
dc.contributor.googleauthor | Soo Kyung Koo | - |
dc.contributor.googleauthor | Ursula C. Dräger | - |
dc.contributor.googleauthor | Doris K. Wu | - |
dc.identifier.doi | 10.1073/pnas.1010547108 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00158 | - |
dc.contributor.localId | A01865 | - |
dc.relation.journalcode | J02550 | - |
dc.identifier.eissn | 1091-6490 | - |
dc.identifier.pmid | 21173260 | - |
dc.subject.keyword | axial specification | - |
dc.subject.keyword | developmental compartments | - |
dc.subject.keyword | morphogen | - |
dc.contributor.alternativeName | Kong, Kyoung Ah | - |
dc.contributor.alternativeName | Bok, Jin Woong | - |
dc.contributor.affiliatedAuthor | Kong, Kyoung Ah | - |
dc.contributor.affiliatedAuthor | Bok, Jin Woong | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 108 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 161 | - |
dc.citation.endPage | 166 | - |
dc.identifier.bibliographicCitation | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol.108(1) : 161-166, 2011 | - |
dc.identifier.rimsid | 28703 | - |
dc.type.rims | ART | - |
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