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Different patterns of neointimal coverage between acute coronary syndrome and stable angina after various types of drug-eluting stents implantation; 9-month follow-up optical coherence tomography study

Authors
 Jung-Sun Kim  ;  Chunyu Fan  ;  Donghoon Choi  ;  Ik-Kyung Jang  ;  Jung Myung Lee  ;  Tae Hoon Kim  ;  Sang Min Park  ;  Sung il Paik  ;  Young-Guk Ko  ;  Myeong-Ki Hong  ;  Yangsoo Jang  ;  Namsik Chung 
Citation
 INTERNATIONAL JOURNAL OF CARDIOLOGY, Vol.146(3) : 341-346, 2011 
Journal Title
 INTERNATIONAL JOURNAL OF CARDIOLOGY 
ISSN
 0167-5273 
Issue Date
2011
MeSH
Acute Coronary Syndrome/pathology* ; Acute Coronary Syndrome/therapy* ; Angina Pectoris/pathology* ; Angina Pectoris/therapy* ; Drug-Eluting Stents* ; Female ; Follow-Up Studies ; Humans ; Male ; Middle Aged ; Neointima/pathology* ; Time Factors ; Tomography, Optical Coherence*
Keywords
Acute coronary syndrome ; Drug-eluting stent ; Tomography ; Optical coherence
Abstract
BACKGROUND: Acute coronary syndrome (ACS) is an independent risk factor for late stent thrombosis which might be related to the impaired vascular healing after drug-eluting stent (DES) due to the disruption of plaques and thrombus formation. Therefore, we investigated the vascular response after various DES implantations between ACS and stable angina pectoris (SAP) using optical coherence tomography (OCT). METHODS: Ninety-one patients [49 ACS: 20 sirolimus-eluting (SES), 12 paclitaxel-eluting (PES) and 17 zotarolimus eluting stent (ZES) and 42 SAP: 15 SES, 12 PES and 15 ZES] underwent OCT at 9 months after stent implantation. Neointimal coverage and malapposition were evaluated in 21,939 struts in 2269-mm stented segments. RESULTS: In the ACS group, the incidence of uncovered and malapposed struts was significantly higher (8.9 ± 13.7 vs 2.9 ± 6.2%, p = 0.01 and 2.2 ± 5.6 vs 0.5 ± 2.0%, p = 0.02). Among the three DESs tested, SES showed a significantly higher rate of uncovered struts in the ACS group (17.3 ± 13.4 vs 4.4 ± 6.2%, p = 0.003). PES had a trend toward higher rate of uncovered and malapposed struts in the ACS groups (6.7 ± 7.6 vs 4.0 ± 9.0%, p = 0.13) while ZES was similar in both groups. CONCLUSION: The patterns of neointimal coverage and malapposition at 9months after DES implantation were different between ACS and SAP, and variable among the DES type between two groups. Therefore, the present study suggests that vascular response after DES implantation might be influenced by both clinical presentation and type of DES.
Full Text
http://www.sciencedirect.com/science/article/pii/S0167527309008006
DOI
10.1016/j.ijcard.2009.07.012
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Ko, Young Guk(고영국) ORCID logo https://orcid.org/0000-0001-7748-5788
Kim, Jung Sun(김중선) ORCID logo https://orcid.org/0000-0003-2263-3274
Kim, Tae-Hoon(김태훈) ORCID logo https://orcid.org/0000-0003-4200-3456
Park, Sang Min(박상민)
Lee, Jung Myung(이정명)
Jang, Yang Soo(장양수) ORCID logo https://orcid.org/0000-0002-2169-3112
Chung, Nam Sik(정남식)
Choi, Dong Hoon(최동훈) ORCID logo https://orcid.org/0000-0002-2009-9760
Hong, Myeong Ki(홍명기) ORCID logo https://orcid.org/0000-0002-2090-2031
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/92651
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