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Different patterns of neointimal coverage between acute coronary syndrome and stable angina after various types of drug-eluting stents implantation; 9-month follow-up optical coherence tomography study

 Jung-Sun Kim  ;  Chunyu Fan  ;  Donghoon Choi  ;  Ik-Kyung Jang  ;  Jung Myung Lee  ;  Tae Hoon Kim  ;  Sang Min Park  ;  Sung il Paik  ;  Young-Guk Ko  ;  Myeong-Ki Hong  ;  Yangsoo Jang  ;  Namsik Chung 
 International Journal of Cardiology, Vol.146(3) : 341-346, 2011 
Journal Title
 International Journal of Cardiology 
Issue Date
BACKGROUND: Acute coronary syndrome (ACS) is an independent risk factor for late stent thrombosis which might be related to the impaired vascular healing after drug-eluting stent (DES) due to the disruption of plaques and thrombus formation. Therefore, we investigated the vascular response after various DES implantations between ACS and stable angina pectoris (SAP) using optical coherence tomography (OCT). METHODS: Ninety-one patients [49 ACS: 20 sirolimus-eluting (SES), 12 paclitaxel-eluting (PES) and 17 zotarolimus eluting stent (ZES) and 42 SAP: 15 SES, 12 PES and 15 ZES] underwent OCT at 9 months after stent implantation. Neointimal coverage and malapposition were evaluated in 21,939 struts in 2269-mm stented segments. RESULTS: In the ACS group, the incidence of uncovered and malapposed struts was significantly higher (8.9 ± 13.7 vs 2.9 ± 6.2%, p = 0.01 and 2.2 ± 5.6 vs 0.5 ± 2.0%, p = 0.02). Among the three DESs tested, SES showed a significantly higher rate of uncovered struts in the ACS group (17.3 ± 13.4 vs 4.4 ± 6.2%, p = 0.003). PES had a trend toward higher rate of uncovered and malapposed struts in the ACS groups (6.7 ± 7.6 vs 4.0 ± 9.0%, p = 0.13) while ZES was similar in both groups. CONCLUSION: The patterns of neointimal coverage and malapposition at 9months after DES implantation were different between ACS and SAP, and variable among the DES type between two groups. Therefore, the present study suggests that vascular response after DES implantation might be influenced by both clinical presentation and type of DES.
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1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
Yonsei Authors
고영국(Ko, Young Guk)
김중선(Kim, Jung Sun) ORCID logo https://orcid.org/0000-0003-2263-3274
김태훈(Kim, Tae-Hoon) ORCID logo https://orcid.org/0000-0003-4200-3456
박상민(Park, Sang Min)
이정명(Lee, Jung Myung)
장양수(Jang, Yang Soo) ORCID logo https://orcid.org/0000-0002-2169-3112
정남식(Chung, Nam Sik)
최동훈(Choi, Dong Hoon) ORCID logo https://orcid.org/0000-0002-2009-9760
홍명기(Hong, Myeong Ki) ORCID logo https://orcid.org/0000-0002-2090-2031
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