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Optimal dose of propofol for intubation after sevoflurane inhalation without neuromuscular blocking agent in children

Authors
 Y. Y. JO ; N. H. JUN ; H. K. KIL ; E. K. CHOI ; E. J. KIM 
Citation
 Acta Anaesthesiologica Scandinavica, Vol.55(3) : 332~336, 2011 
Journal Title
 Acta Anaesthesiologica Scandinavica 
ISSN
 0001-5172 
Issue Date
2011
Abstract
BACKGROUND: This study was designed to determine the optimal dose of propofol for excellent intubating conditions in children without neuromuscular blockade at various alveolar concentrations of sevoflurane. METHODS: Sixty-three children, aged 0.5-5 years, were randomized to three groups of end-tidal sevoflurane concentration (ETsevo) 3%, 3.5%, and 4%. Inhalation anesthesia was started with sevoflurane 7% in 100% oxygen. When the patients became unconscious, inspired concentration was adjusted to obtain the target ETsevo for each group. When ETsevo reached the target concentration, a predetermined dose of propofol was given and tracheal intubation was performed. The proper dose of propofol was determined using the 'up-and-down' method. RESULTS: The median dose (95% confidence intervals) of propofol for excellent tracheal intubating conditions in 50% of children were 1.25 mg/kg (0.84-1.75) at ETsevo of 3%, 0.76 mg/kg (0.35-1.21) at 3.5%, and 0.47 mg/kg (0.26-1.09) at 4%. The frequency of adverse effects was not different between groups during induction and recovery. CONCLUSION: Propofol 1.5-2 mg/kg provides excellent intubating conditions at 3-4% ETsevo in children without using any neuromuscular blocking agent.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/92628
DOI
10.1111/j.1399-6576.2010.02383.x
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Anesthesiology and Pain Medicine
Yonsei Authors
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Link
 http://onlinelibrary.wiley.com/doi/10.1111/j.1399-6576.2010.02383.x/abstract
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