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Effects of pregnane X receptor (NR1I2) and CYP2B6 genetic polymorphisms on the induction of bupropion hydroxylation by rifampin.

DC Field Value Language
dc.contributor.author정재용-
dc.date.accessioned2014-12-20T16:23:03Z-
dc.date.available2014-12-20T16:23:03Z-
dc.date.issued2011-
dc.identifier.issn0090-9556-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/92613-
dc.description.abstractWe investigated genetic polymorphisms in the pregnane X receptor (NR1I2) in Korean individuals (n = 83) and the effects of NR1I2 genotypes on rifampin-mediated induction of bupropion hydroxylation. The pharmacokinetics of bupropion and hydroxybupropion were evaluated after an oral dose of bupropion (150 mg) administered before and after rifampin treatment for 7 days in 35 healthy subjects. The area under the time-concentration curve (AUC) ratio of hydroxybupropion to bupropion in CYP2B6*6 carriers was significantly lower than that in CYP2B6*6 noncarriers in both the basal and rifampin-induced states (p = 0.012). Among the CYP2B6*6 carriers (n = 13), the NR1I2 TGT (-25385T + g.7635G + g.8055T) carriers exhibited a significantly lower AUC ratio, representing the CYP2B6 hydroxylation activity, compared with the TGT noncarriers, in the induced state (11.9 versus 20.3, p = 0.045). The percent difference in the AUC ratio between the basal and induced states was also significantly different (212% versus 58.8%, p = 0.006). However, no significant difference was observed among the NR1I2 TGT genotypes for the CYP2B6*6 noncarriers (n = 22). In conclusion, it is suggested the NR1I2 TGT genotype decreases the bupropion hydroxylation induced by treatment with rifampin, particularly in CYP2B6*6 carriers.-
dc.description.statementOfResponsibilityopen-
dc.format.extent92~97-
dc.relation.isPartOfDRUG METABOLISM AND DISPOSITION-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAryl Hydrocarbon Hydroxylases/genetics*-
dc.subject.MESHAryl Hydrocarbon Hydroxylases/metabolism-
dc.subject.MESHAsian Continental Ancestry Group/genetics-
dc.subject.MESHBupropion/analogs & derivatives*-
dc.subject.MESHBupropion/blood-
dc.subject.MESHBupropion/metabolism*-
dc.subject.MESHCytochrome P-450 CYP2B6-
dc.subject.MESHDrug Interactions-
dc.subject.MESHFemale-
dc.subject.MESHGenotype-
dc.subject.MESHHumans-
dc.subject.MESHHydroxylation-
dc.subject.MESHMale-
dc.subject.MESHOxidoreductases, N-Demethylating/genetics*-
dc.subject.MESHOxidoreductases, N-Demethylating/metabolism-
dc.subject.MESHPolymorphism, Single Nucleotide*-
dc.subject.MESHReceptors, Steroid/genetics*-
dc.subject.MESHReceptors, Steroid/metabolism-
dc.subject.MESHRifampin/pharmacology*-
dc.titleEffects of pregnane X receptor (NR1I2) and CYP2B6 genetic polymorphisms on the induction of bupropion hydroxylation by rifampin.-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Pharmacology (약리학)-
dc.contributor.googleauthorJae Yong Chung-
dc.contributor.googleauthorJoo-Youn Cho-
dc.contributor.googleauthorHyeong-Seok Lim-
dc.contributor.googleauthorJung-Ryul Kim-
dc.contributor.googleauthorKyung-Sang Yu-
dc.contributor.googleauthorKyoung Soo Lim-
dc.contributor.googleauthorSang-Goo Shin-
dc.contributor.googleauthorIn-Jin Jang-
dc.identifier.doi10.1124/dmd.110.035246-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA03709-
dc.relation.journalcodeJ00749-
dc.identifier.eissn1521-009X-
dc.identifier.pmid20876786-
dc.contributor.alternativeNameChung, Jae Yong-
dc.contributor.affiliatedAuthorChung, Jae Yong-
dc.rights.accessRightsfree-
dc.citation.volume39-
dc.citation.number1-
dc.citation.startPage92-
dc.citation.endPage97-
dc.identifier.bibliographicCitationDRUG METABOLISM AND DISPOSITION, Vol.39(1) : 92-97, 2011-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pharmacology (약리학교실) > 1. Journal Papers

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