Cited 17 times in
Tissue transglutaminase 2 promotes apoptosis of rat neonatal cardiomyocytes under oxidative stress
DC Field | Value | Language |
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dc.contributor.author | 송병욱 | - |
dc.contributor.author | 장양수 | - |
dc.contributor.author | 차민지 | - |
dc.contributor.author | 황기철 | - |
dc.date.accessioned | 2014-12-20T16:22:03Z | - |
dc.date.available | 2014-12-20T16:22:03Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 1079-9893 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/92585 | - |
dc.description.abstract | The role of tissue transglutaminase 2 (TG2) in cardiac myocyte apoptosis under oxidative stress induced by ischemic injury remains unclear. Here, we investigated the effects of TG2 on apoptosis of cardiomyocytes under oxidative stress. Ectopic expression of TG2 increased caspase-3 activity and calcium overload in cardiomyocytes. Expression levels of TG2 were significantly increased in H(2)O(2)-treated cardiomyocytes. Caspase-3 activity assay demonstrated its considerable correlation with TG2 expression, which supported that caspase-3 inhibitor inhibited the apoptosis induced by the ectopic overexpression of TG2. In addition, the other apoptotic signals, such as caspase-8, cytochrome c, and Bax, were increased dependent with TG2 expression in H(2)O(2)-treated cardiomyocytes. These results indicated that apoptotic signals had a positive correlation with TG2 expression. The decreased expression of phospholipase C (PLC)-δ1 and phospho-PKC in H(2)O(2)-treated cardiomyocytes were rescued by TG2 silencing. Together, our data strongly suggest that oxidative stress up-regulates TG2 expression in cardiomyocytes, leading to apoptosis. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Animals, Newborn | - |
dc.subject.MESH | Apoptosis*/drug effects | - |
dc.subject.MESH | Caspase 3/metabolism | - |
dc.subject.MESH | Cell Survival/drug effects | - |
dc.subject.MESH | GTP-Binding Proteins/metabolism* | - |
dc.subject.MESH | Gene Silencing/drug effects | - |
dc.subject.MESH | Hydrogen Peroxide/pharmacology | - |
dc.subject.MESH | Myocytes, Cardiac/cytology* | - |
dc.subject.MESH | Myocytes, Cardiac/drug effects | - |
dc.subject.MESH | Myocytes, Cardiac/enzymology* | - |
dc.subject.MESH | Oxidative Stress*/drug effects | - |
dc.subject.MESH | Rats | - |
dc.subject.MESH | Signal Transduction/drug effects | - |
dc.subject.MESH | Transglutaminases/metabolism* | - |
dc.subject.MESH | Up-Regulation/drug effects | - |
dc.title | Tissue transglutaminase 2 promotes apoptosis of rat neonatal cardiomyocytes under oxidative stress | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Heesang Song | - |
dc.contributor.googleauthor | Byoung-Keuk Kim | - |
dc.contributor.googleauthor | Woochul Chang | - |
dc.contributor.googleauthor | Soyeon Lim | - |
dc.contributor.googleauthor | Byeong-Wook Song | - |
dc.contributor.googleauthor | Min-Ji Cha | - |
dc.contributor.googleauthor | Yangsoo Jang | - |
dc.contributor.googleauthor | Ki-Chul Hwang | - |
dc.identifier.doi | 10.3109/10799893.2010.529577 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00493 | - |
dc.contributor.localId | A02026 | - |
dc.contributor.localId | A03448 | - |
dc.contributor.localId | A03995 | - |
dc.contributor.localId | A04456 | - |
dc.relation.journalcode | J01728 | - |
dc.identifier.eissn | 1532-4281 | - |
dc.identifier.pmid | 21067463 | - |
dc.identifier.url | http://informahealthcare.com/doi/abs/10.3109/10799893.2010.529577 | - |
dc.subject.keyword | Apoptosis | - |
dc.subject.keyword | cardiomyocytes | - |
dc.subject.keyword | hydrogen peroxide | - |
dc.subject.keyword | TG2 | - |
dc.subject.keyword | calcium | - |
dc.contributor.alternativeName | Song, Byeong Wook | - |
dc.contributor.alternativeName | Jang, Yang Soo | - |
dc.contributor.alternativeName | Cha, Min Ji | - |
dc.contributor.alternativeName | Hwang, Ki Chul | - |
dc.contributor.affiliatedAuthor | Song, Byeong Wook | - |
dc.contributor.affiliatedAuthor | Jang, Yang Soo | - |
dc.contributor.affiliatedAuthor | Cha, Min Ji | - |
dc.contributor.affiliatedAuthor | Hwang, Ki Chul | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 31 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 66 | - |
dc.citation.endPage | 74 | - |
dc.identifier.bibliographicCitation | JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION, Vol.31(1) : 66-74, 2011 | - |
dc.identifier.rimsid | 28646 | - |
dc.type.rims | ART | - |
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