1 507

Cited 15 times in

Monocyte chemoattractant protein-1 is related to metabolic syndrome and homocysteine in subjects without clinically significant atherosclerotic cardiovascular disease

DC Field Value Language
dc.contributor.author이지원-
dc.date.accessioned2014-12-20T16:20:50Z-
dc.date.available2014-12-20T16:20:50Z-
dc.date.issued2011-
dc.identifier.issn0036-5513-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/92546-
dc.description.abstractBACKGROUND: The features of the metabolic syndrome include glucose intolerance, hypertension, dyslipidemia, and central obesity, all of which are risk factors for diabetes and cardiovascular disease. Monocyte chemoattractant protein-1 (MCP-1) and interleukin-8 (IL-8) play a key role in atherosclerosis. We examined the association between chemokines, such as MCP-1 and IL-8, and metabolic syndrome. METHODS: The present study was comprised of 54 men and 126 women. Subjects with cardiovascular disease such as myocardial infarction, TIA and cerebral infarction were excluded. RESULTS: MCP-1 was positively correlated with homeostasis model assessment of insulin resistance, homocysteine, and mean pulse wave velocity, but IL-8 was not. In multiple regression analysis, age, HOMA-IR and homocysteine were found to be an independent factor associated with MCP-1 adjusted by gender, waist, systolic blood pressure, triglyceride, HDL-cholesterol, and hs-CRP. After adjustment for age and gender, mean MCP-1 was higher in subjects with metabolic syndrome and in subject with high blood pressure among the individual components of the metabolic syndrome. CONCLUSION: MCP-1 was associated with a low-grade systemic inflammatory reaction which is often found in the metabolic syndrome-
dc.description.statementOfResponsibilityopen-
dc.format.extent1~6-
dc.relation.isPartOfSCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleMonocyte chemoattractant protein-1 is related to metabolic syndrome and homocysteine in subjects without clinically significant atherosclerotic cardiovascular disease-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Family Medicine (가정의학)-
dc.contributor.googleauthorSang-Hwan Kim-
dc.contributor.googleauthorJi-Won Lee-
dc.contributor.googleauthorJee-Aee Im-
dc.contributor.googleauthorHee-Jin Hwang-
dc.identifier.doi10.3109/00365513.2010.519047-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA03203-
dc.relation.journalcodeJ02631-
dc.identifier.eissn1502-7686-
dc.identifier.urlhttp://informahealthcare.com/doi/abs/10.3109/00365513.2010.519047-
dc.subject.keywordMCP-1-
dc.subject.keywordhomocysteine-
dc.subject.keywordinsulin resistance-
dc.subject.keywordmetabolic syndrome-
dc.subject.keywordarterial stiffness-
dc.contributor.alternativeNameLee, Ji Won-
dc.contributor.affiliatedAuthorLee, Ji Won-
dc.rights.accessRightsnot free-
dc.citation.volume71-
dc.citation.number1-
dc.citation.startPage1-
dc.citation.endPage6-
dc.identifier.bibliographicCitationSCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION, Vol.71(1) : 1-6, 2011-
dc.identifier.rimsid28626-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Family Medicine (가정의학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.