Cited 15 times in
Monocyte chemoattractant protein-1 is related to metabolic syndrome and homocysteine in subjects without clinically significant atherosclerotic cardiovascular disease
DC Field | Value | Language |
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dc.contributor.author | 이지원 | - |
dc.date.accessioned | 2014-12-20T16:20:50Z | - |
dc.date.available | 2014-12-20T16:20:50Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 0036-5513 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/92546 | - |
dc.description.abstract | BACKGROUND: The features of the metabolic syndrome include glucose intolerance, hypertension, dyslipidemia, and central obesity, all of which are risk factors for diabetes and cardiovascular disease. Monocyte chemoattractant protein-1 (MCP-1) and interleukin-8 (IL-8) play a key role in atherosclerosis. We examined the association between chemokines, such as MCP-1 and IL-8, and metabolic syndrome. METHODS: The present study was comprised of 54 men and 126 women. Subjects with cardiovascular disease such as myocardial infarction, TIA and cerebral infarction were excluded. RESULTS: MCP-1 was positively correlated with homeostasis model assessment of insulin resistance, homocysteine, and mean pulse wave velocity, but IL-8 was not. In multiple regression analysis, age, HOMA-IR and homocysteine were found to be an independent factor associated with MCP-1 adjusted by gender, waist, systolic blood pressure, triglyceride, HDL-cholesterol, and hs-CRP. After adjustment for age and gender, mean MCP-1 was higher in subjects with metabolic syndrome and in subject with high blood pressure among the individual components of the metabolic syndrome. CONCLUSION: MCP-1 was associated with a low-grade systemic inflammatory reaction which is often found in the metabolic syndrome | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 1~6 | - |
dc.relation.isPartOf | SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Monocyte chemoattractant protein-1 is related to metabolic syndrome and homocysteine in subjects without clinically significant atherosclerotic cardiovascular disease | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Family Medicine (가정의학) | - |
dc.contributor.googleauthor | Sang-Hwan Kim | - |
dc.contributor.googleauthor | Ji-Won Lee | - |
dc.contributor.googleauthor | Jee-Aee Im | - |
dc.contributor.googleauthor | Hee-Jin Hwang | - |
dc.identifier.doi | 10.3109/00365513.2010.519047 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A03203 | - |
dc.relation.journalcode | J02631 | - |
dc.identifier.eissn | 1502-7686 | - |
dc.identifier.url | http://informahealthcare.com/doi/abs/10.3109/00365513.2010.519047 | - |
dc.subject.keyword | MCP-1 | - |
dc.subject.keyword | homocysteine | - |
dc.subject.keyword | insulin resistance | - |
dc.subject.keyword | metabolic syndrome | - |
dc.subject.keyword | arterial stiffness | - |
dc.contributor.alternativeName | Lee, Ji Won | - |
dc.contributor.affiliatedAuthor | Lee, Ji Won | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 71 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 1 | - |
dc.citation.endPage | 6 | - |
dc.identifier.bibliographicCitation | SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION, Vol.71(1) : 1-6, 2011 | - |
dc.identifier.rimsid | 28626 | - |
dc.type.rims | ART | - |
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