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Progression rate from new-onset pre-hypertension to hypertension in Korean adults

 Soo Jeong Kim  ;  Jakyoung Lee  ;  Chung Mo Nam  ;  Sun Ha Jee  ;  Il Soo Park  ;  Kyung Jong Lee  ;  Soon Young Lee 
 CIRCULATION JOURNAL, Vol.75(1) : 135-140, 2011 
Journal Title
Issue Date
Adult ; Age Distribution ; Asian Continental Ancestry Group/statistics & numerical data* ; Blood Pressure* ; Disease Progression ; Female ; Follow-Up Studies ; Humans ; Hypertension/ethnology* ; Hypertension/physiopathology ; Incidence ; Male ; Middle Aged ; Prehypertension/ethnology* ; Prehypertension/physiopathology ; Republic of Korea/epidemiology ; Risk Assessment ; Risk Factors ; Sex Distribution ; Sex Factors ; Time Factors
Epidemiology ; Follow-up studies ; Hypertension ; Population
BACKGROUND: There are limited studies conducted in Asia to investigate the progression rate to hypertension (HTN). This study was done to estimate the progression rate of new-onset pre-HTN (PreHTN) to HTN during an 8-year follow-up period, and to compare the impact of PreHTN on progression to HTN.

METHODS AND RESULTS: A total of 49,228 participants, aged 30 to 54 years with new-onset PreHTN at baseline (1994-1996) from a biennial national medical exam were enrolled and followed up every 2 years until 2004. The incidence rate recorded at each interval and the cumulative incidence rate of HTN were analyzed. Hazard ratio of high-normal and high blood pressure (BP) in men and women was calculated. The cumulative incidence rate for high-normal BP was 27.6% and 26.4% at 2-year follow-up, increased to respectively 64.1% and 55.8% in men and women at the 8-year follow-up. Compared to optimal BP, hazard ratios for men with high-normal BP across all age groups were 3- to 4-fold higher at 2-year, and 2- to 3-fold higher at 8-year follow-up. Hazard ratios for women were about 6-fold higher at 2-year and around 4-fold higher at 8-year follow-up.

CONCLUSIONS: New PreHTN was a significant predisposing factor for future HTN, in young adults and the effect is more prominent in women.
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1. College of Medicine (의과대학) > Dept. of Preventive Medicine (예방의학교실) > 1. Journal Papers
4. Graduate School of Public Health (보건대학원) > Graduate School of Public Health (보건대학원) > 1. Journal Papers
Yonsei Authors
Nam, Chung Mo(남정모) ORCID logo https://orcid.org/0000-0003-0985-0928
Jee, Sun Ha(지선하) ORCID logo https://orcid.org/0000-0001-9519-3068
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