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조현병 및 조현정동장애 입원환자에서 혈청 염증표지자와 정신병적증상과의 관련성

Other Titles
 Relationship between Serum Inflammatory Marker and Psychotic Symptoms in Inpatients with Schizophrenia or Schizoaffective Disorder 
Authors
 김계환  ;  이건석  ;  김수진  ;  이은규  ;  송열매  ;  박진영 
Citation
 Korean Journal of Biological Psychiatry (생물정신의학), Vol.19(4) : 193-198, 2012 
Journal Title
 Korean Journal of Biological Psychiatry (생물정신의학) 
ISSN
 1225-8709 
Issue Date
2012
Keywords
C-reactive protein ; Inflammatory marker ; Schizophrenia ; Positive symptoms
Abstract
Objectives : Despite the growing research interest in the role of immunological markers in schizophrenia, a few studies, with conflicting results, have focused on the association between high sensitivity C-reactive protein (hs-CRP) levels and clinical characteristics in schizophrenia. The aim of the present study was to examine the association of serum hs-CRP with psychopathology in schizophrenia. Methods : Fifty-five inpatients with schizophrenia or schizoaffective disorder were enrolled. Serum levels of hs-CRP were measured, and each patient was assessed with the Korean version of the Positive and Negative Syndrome Scale (PANSS). Results : In correlation analysis of hs-CRP with PANSS subscales, positive subscale score has significant positive correlation (r = 0.271, p = 0.046). In independent t-test analysis, subjects with hs-CRP > 0.3 mg/dL (elevated CRP group, n = 43) had significantly higher PANSS positive subscale score (t = -3.273, df = 24.107, p = 0.003) than those with hs-CRP ≤ 0.3 mg/dL (normal CRP group, n = 12). Conclusions : Elevated serum levels of high sensitivity C-reactive protein in schizophrenia are associated with the severity of psychotic symptoms.
Files in This Item:
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
Yonsei Authors
Park, Jin Young(박진영) ORCID logo https://orcid.org/0000-0002-5351-9549
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/92432
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