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임신 중 내분비계 장애물질 Bisphenol A의 양수 내 농도와 임신결과와의 상관관계

Other Titles
 Amniotic Fluid Bisphenol A Level and Its Relationship with Pregnancy Outcomes 
Authors
 윤정미  ;  권자영  ;  윤용달  ;  김세광 
Citation
 Development & Reproduction (발생과 생식), Vol.16(2) : 95-100, 2012 
Journal Title
 Development & Reproduction (발생과 생식) 
ISSN
 1226-6752 
Issue Date
2012
Keywords
Bisphenol A ; Amniotic fluid ; Human pregnancy ; Developing embryo
Abstract
ABSTRACT : Bisphenol A (BPA), a chemical with weak estrogenic activity is reported to affect preimplantation embryos, fetuses and alter their postnatal development. This study amied to determine the relation between the levels of BPA in the amniotic fluid and pregnancy outcomes. ELISA was used to measure amniotic fluid BPA in 120 pregnant women who underwent genetic amniocentesis at 15~20 weeks gestation. The most common indication for amniocentesis was advanced maternal age (35 yrs or older). BPA was detected in all amniotic fluid. The range of amniotic fluid BPA concentrations was from 0.89 ng/mL to 37.13 ng/mL with a mean level of 7.24 ng/mL. We compared the means of amniotic fluid BPA concentrations according to maternal age (≥35 vs. <35 yrs), fetal sex (male vs. female), gestational age at birth (≥37 vs. <37 weeks), and infant birth weight (≥2.5 vs. <2.5 kg). No significant differences were found in these outcomes. This is the first report of amniotic fluid BPA levels in Korean pregnant women. Our findings suggest that BPA may not affect the pregnancy outcomes such as fetal sex, preterm delivery and low birth weight. Whether prenatal exposure to BPA can have teratogenic effect on developing embryo needs to be studied.
Files in This Item:
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers
Yonsei Authors
Kwon, Ja Young(권자영) ORCID logo https://orcid.org/0000-0003-3009-6325
Kim, Sei Kwang(김세광)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/92417
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