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Squamous cell carcinoma showing rapid metastasis after leg amputation due to chronic osteomyelitis

 Jong Hoon Kim  ;  Sang Hee Lee  ;  Mi Ryung Roh 
 Korean Journal of Dermatology (대한피부과학회지), Vol.50(6) : 574-576, 2012 
Journal Title
 Korean Journal of Dermatology (대한피부과학회지) 
Issue Date
Amputation ; Marjolin`s ulcer ; Rapid metastasis ; Squamous cell carcinoma
Marjolin`s ulcer is a malignant lesion, which arises in a chronic wound. When squamous cell carcinoma occurs in Marjolin`s ulcer, the prognosis is known to be worse than that of cutaneous squamous cell carcinoma, due to other etiologies. A 56-year-old male who was diagnosed as chronic osteomyelitis was recommended for a surgical amputation of the left lower leg. After amputation, the histology of chronic ulcer revealed squamous cell carcinoma. In a few months period, multiple suppurative ulcers and nodules appeared near the amputation stump, as well as the proximal sites of the left leg, which appeared to spread rapidly. Biopsy of a representative lesion and positron emission tomography-computed tomography revealed a metastatic squamous cell carcinoma and malignant lymphadenopathy. Aggressive amputation without appropriate preoperative evaluation to detect the locoregional metastasis may be an inadequate option of the treatment for the patient due to a rapid spread of cancer metastasis, which may happen immediately after an amputation. Therefore, it is important to obtain a thorough preoperative evaluation of recalcitrant ulcer from osteomyelitis before the decision to undergo an amputation.
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1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jong Hoon(김종훈) ORCID logo https://orcid.org/0000-0002-3385-8180
Roh, Mi Ryung(노미령) ORCID logo https://orcid.org/0000-0002-6285-2490
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