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확률적 보상과제를 이용한 기분안정기 양극성 장애 환자의 보상학습 특성

Other Titles
 Reward Learning in Euthymic Patients with Bipolar Disorder Using a Probabilistic Reward Task 
 김태영  ;  유빈  ;  조현상  ;  하규섭  ;  이수진  ;  하라연 
 Korean Journal of Psychopharmacology (대한정신약물학회지), Vol.23(1) : 28-35, 2012 
Journal Title
 Korean Journal of Psychopharmacology  (대한정신약물학회지) 
Issue Date
Objective Bipolar disorder patients often show excessive goal-directed and pleasure-seeking behavior during manic episodes and reduced hedonic capacity during depressive episodes, indicating that bipolar disorder might involve altered reward processing. As such, bipolar disorder subjects have been reported to show impaired reward learning in situations requiring integration of reinforcements over time. In this study, we examined characteristics of reward learning in euthymic patients with bipolar disorder using a probabilistic reward task. Methods We recruited 23 euthymic patients with bipolar disorder and 47 healthy subjects for the probabilistic reward task. This task is a reward-based paradigm to produce a response bias, in which correct identifications of two ambiguous stimuli are differently rewarded. The other dependent measures were the discriminability, hit rate and reaction time. Results Relative to comparison subjects, bipolar patients showed a reduced acquisition of response bias toward the more frequently rewarded stimulus (p<0.01). The overall reward learning was positively correlated with state and trait anxiety levels in bipolar patients (p<0.01). No significant differences of discriminability, hit rates, and reaction time were found between bipolar patients and controls. Conclusion These findings suggest that euthymic patients with bipolar disorder may have deficits in reward learning related to anxiety.
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1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실)
Yonsei Authors
조현상(Cho, Hyun Sang) ; 하라연(Ha, Ra Yeon)
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