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Changes in Serum Cytokine Profile after AEB071 (Sotrastaurin) or Tacrolimus versus Their Combinations in Rat Heterotopic Cardiac Allografts.
DC Field | Value | Language |
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dc.contributor.author | 서활 | - |
dc.contributor.author | 주동진 | - |
dc.contributor.author | 허규하 | - |
dc.contributor.author | 김명수 | - |
dc.contributor.author | 김유선 | - |
dc.date.accessioned | 2014-12-19T17:55:41Z | - |
dc.date.available | 2014-12-19T17:55:41Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 1298-1711 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/92322 | - |
dc.description.abstract | BACKGROUND: AEB071, an orally available PKC inhibitor, prevents organ rejection after transplantation in rodents and man. Furthermore, pro-inflammatory cytokines and inflammatory processes are important mediators of transplanted organ rejection. We therefore examined whether single or combination therapies of AEB071 and/or tacrolimus affect cytokine profiles in a rat cardiac allograft model. METHODS: AEB071 (60 mg/kg twice a day) and tacrolimus (0.6 or 1.2 mg/kg once a day) were orally administered daily after cardiac transplantation. Interferon (IFN)-gamma, interleukin (IL)-1beta, IL-2, IL-4, IL-6, IL-10, and tumor necrosis factor (TNF)-alpha levels in serum were subsequently measured 5 days after cardiac transplantation using a multiplex protein assay system. RESULTS: All cytokine levels were significantly depressed in cardiac transplanted rats treated with AEB071, whereas tacrolimus only reduced IFN-gamma, IL-2, IL-4, IL-6, and IL-10 levels. When administered in combination, AEB071 and low- or high-dose tacrolimus had additive effects on IFN-gamma, IL-4, IL-6, and TNF-alpha. CONCLUSIONS: These results suggest that AEB071 inhibits T cell activation by blocking the production of proinflammatory cytokines, and that tacrolimus combined with AEB071 can effectively regulate inflammatory cytokines in the transplantation setting. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 248~253 | - |
dc.language | Journal of the Korean Society for Transplantation | - |
dc.publisher | Journal of the Korean Society for Transplantation | - |
dc.relation.isPartOf | Journal of the Korean Society for Transplantation | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Changes in Serum Cytokine Profile after AEB071 (Sotrastaurin) or Tacrolimus versus Their Combinations in Rat Heterotopic Cardiac Allografts. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Medical Engineering (의학공학) | - |
dc.contributor.googleauthor | Dong Jin Joo | - |
dc.contributor.googleauthor | Yu Hui Fang | - |
dc.contributor.googleauthor | Kyu Ha Huh | - |
dc.contributor.googleauthor | Myoung Soo Kim | - |
dc.contributor.googleauthor | Hwal Suh | - |
dc.contributor.googleauthor | Yu Seun Kim | - |
dc.identifier.doi | 10.4285/jkstn.2012.26.4.248 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01924 | - |
dc.contributor.localId | A03948 | - |
dc.contributor.localId | A04344 | - |
dc.contributor.localId | A00785 | - |
dc.contributor.localId | A00424 | - |
dc.relation.journalcode | J01858 | - |
dc.identifier.eissn | 2508-2604 | - |
dc.identifier.pmid | Sotrastaurin ; Cytokines ; Heart transplantation ; Immunosuppression ; Tacrolimus | - |
dc.subject.keyword | Sotrastaurin | - |
dc.subject.keyword | Cytokines | - |
dc.subject.keyword | Heart transplantation | - |
dc.subject.keyword | Immunosuppression | - |
dc.subject.keyword | Tacrolimus | - |
dc.contributor.alternativeName | Suh, Hwal | - |
dc.contributor.alternativeName | Joo, Dong Jin | - |
dc.contributor.alternativeName | Huh, Kyu Ha | - |
dc.contributor.alternativeName | Kim, Myoung Soo | - |
dc.contributor.alternativeName | Kim, Yu Seun | - |
dc.contributor.affiliatedAuthor | Suh, Hwal | - |
dc.contributor.affiliatedAuthor | Joo, Dong Jin | - |
dc.contributor.affiliatedAuthor | Huh, Kyu Ha | - |
dc.contributor.affiliatedAuthor | Kim, Yu Seun | - |
dc.contributor.affiliatedAuthor | Kim, Myoung Soo | - |
dc.citation.volume | 26 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 248 | - |
dc.citation.endPage | 253 | - |
dc.identifier.bibliographicCitation | Journal of the Korean Society for Transplantation, Vol.26(4) : 248-253, 2012 | - |
dc.identifier.rimsid | 29416 | - |
dc.type.rims | ART | - |
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