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기억 T 세포 매개 이식장기 손상의 치료방안

Other Titles
 Strategies to Overcome Memory T Cells Mediatied Allograft Injury. 
Authors
 김범석 
Citation
 Journal of the Korean Society for Transplantation (대한이식학회지), Vol.26(2) : 69-73, 2012 
Journal Title
 Journal of the Korean Society for Transplantation  (대한이식학회지) 
ISSN
 1598-1711 
Issue Date
2012
Abstract
During the last few decades our knowledge of transplantation has been remarkably expanded to the point where transplants are a standard treatment modality. However, despite the fact that certain tolerogenic protocols seemed to be very successful in small animal models, researchers anticipated the same outcomes in humans, which has mostly not been true yet. Immunological memory is known to be one of the reasons for such discrepancies. Donor-specific memory T cells are thought to be a crucial barrier in transplant success due to their unique properties. Recently, efforts to overcome this issue have been made, and several protocols showed the inhibition of memory T cell functions both in vitro and in vivo. In this review, we discuss the role of memory T cells in transplant rejection and the rising strategies to overcome this barrier.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/92319
Files in This Item:
T201203262.pdf Download
DOI
10.4285/jkstn.2012.26.2.69
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
Yonsei Authors
김범석(Kim, Beom Seok)
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