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Most Transmitted Glomerular Lesions in a Zero-Hour Biopsy of Allograft Kidney Have No Clinical Significance

 Beom Jin Lim  ;  Dong Jin Joo  ;  Yu Seun Kim  ;  Hyeon Joo Jeong 
 Journal of the Korean Society for Transplantation (대한이식학회지), Vol.26(3) : 174-177, 2012 
Journal Title
 Journal of the Korean Society for Transplantation (대한이식학회지) 
Issue Date
Glomerulonephritis ; Kidney transplantation ; Time-zero renal biopsy
Background: The clinical significance of glomerular lesions detected in zero-hour renal allograft biopsies have yet to be fully examined. Methods: We retrospectively reviewed 229 zero-hour renal allograft biopsies, and investigated the prevalence of transmitted glomerular lesions and their association with urinary abnormalities. Results: Of 117 cases to which immunofluorescence microscopy was applied, immune complex-associated glomerular lesions were found in eight cases (6.8%). Seven cases were diagnosed with immunoglobulin A nephropathy and none accompanied significant urinary abnormalities during the mean follow-up period of 21.9 months. The other case was diagnosed as C1q nephropathy, revealing significant proteinuria and hematuria 1 month after transplantation. The remaining glomerular abnormalities included focal segmental glomerular sclerosis in five cases, focal endocapillary leukocyte infiltration in three cases, and glomerular fibrin thrombi in three cases. Urinary abnormalities were absent during the follow-up period in all of the cases. Conclusions: Our observations suggest that most of the transmitted glomerular lesions were clinically irrelevant and that a renal biopsy is unnecessary to include in a pre-transplant donor evaluation procedure.
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1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Yu Seun(김유선) ORCID logo https://orcid.org/0000-0002-5105-1567
Lim, Beom Jin(임범진) ORCID logo https://orcid.org/0000-0003-2856-0133
Jeong, Hyeon Joo(정현주) ORCID logo https://orcid.org/0000-0002-9695-1227
Joo, Dong Jin(주동진) ORCID logo https://orcid.org/0000-0001-8405-1531
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