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Impact of early-life stress and resilience on patients with major depressive disorder

 Jeong-Ho Seok  ;  Kyoung-Uk Lee  ;  Won Kim  ;  Seung-Hwan Lee  ;  Eun-Ho Kang  ;  Byung-Joo Ham  ;  Jong-Chul Yang  ;  Jeong-Ho Chae 
 YONSEI MEDICAL JOURNAL, Vol.53(6) : 1093-1098, 2012 
Journal Title
Issue Date
Adolescent ; Adult ; Case-Control Studies ; Child ; Child Abuse ; Depressive Disorder, Major/epidemiology* ; Female ; Humans ; Male ; Psychopathology ; Resilience, Psychological* ; Risk Factors ; Stress, Psychological* ; Surveys and Questionnaires
Resilience ; self-confidence ; self-control ; inter-parental violence ; depressive disorder
PURPOSE: Early-life stress (ELS) has a long-lasting effect on affective function and may entail an increased risk for major depressive disorder (MDD). However, resilience can play a protective role against developing psychopathology. In this study, we investigated the relationships of depressive symptoms with ELS and resilience in MDD. MATERIALS AND METHODS: Twenty-six patients with MDD as well as age- and gender-matched healthy controls were included in this study. Each subject was assessed concerning ELS, resilience, and depressive symptom severity with self-report questionnaires. Independent samples t-test and Mann-Whitney test were performed to compare ELS and resilience between the patient and control groups. Spearman correlation analyses and linear regression analysis were conducted to investigate significant ELS and resilience factors associated with depressive symptoms. RESULTS: In the MDD patient group, subjects reported greater exposure to inter- parental violence, and five factor scores on the resilience scale were significantly lower in comparison to the control group. In linear regression analysis, in regards to resilience, depressive symptom score was significantly associated with self-confidence and self-control factors; however, ELS demonstrated no significant association with depressive symptoms. CONCLUSION: Among resilience factors, self-confidence and self-control may ameliorate depressive symptoms in MDD. ELS, including inter-parental violence, physical abuse and emotional abuse, might be a risk factor for developing depression. Assessment of early-life stress and intervention programs for increasing resilience capacity would be helpful in treating MDD.
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1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
Yonsei Authors
Seok, Jeong Ho(석정호) ORCID logo https://orcid.org/0000-0002-9402-7591
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