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How many valid measurements are necessary to assess liver fibrosis using FibroScan® in patients with chronic viral hepatitis? An analysis of subjects with at least 10 valid measurements

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dc.contributor.author안상훈-
dc.contributor.author장희원-
dc.contributor.author전재윤-
dc.contributor.author한광협-
dc.contributor.author김도영-
dc.contributor.author김승업-
dc.contributor.author박영년-
dc.contributor.author박준용-
dc.date.accessioned2014-12-19T17:49:21Z-
dc.date.available2014-12-19T17:49:21Z-
dc.date.issued2012-
dc.identifier.issn0513-5796-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/92124-
dc.description.abstractPURPOSE: Using FibroScan® to obtain a reliable liver stiffness measurement (LSM) may require more than 10 valid measurements (VMs), according to the manufacturer's recommendations. However, this requirement lacks scientific evidence in support thereof. We investigated the minimal number of VMs required to assess liver fibrosis without significant loss of accuracy in patients with chronic hepatitis B (CHB) and C (CHC) and predictors of discordance between LSM and liver biopsy (LB). MATERIALS AND METHODS: Between January 2005 and December 2009, we prospectively enrolled 182 patients with CHB and 68 patients with CHC who were to undergo LB and LSM before starting antiviral treatment. Only LSMs with at least 10 VMs were considered reliable. The Batts and Ludwig scoring system was used for histologic assessment. RESULTS: The mean age and body mass index were 46.0 years and 23.4 kg/m² in patients with CHB and 49.7 years and 23.1 kg/m² in those with CHC, respectively. The median elasticity scores from the first 3, first 5, and all VMs taken significantly predicted fibrosis stages ≥F2 and F4 (all p<0.05) without significant differences (all p>0.05 by DeLong's method). Alanine aminotransferase (ALT) was the only predictor of discordance in fibrosis stage as estimated by the median elasticity score from the first 3 VMs and by LB in patients with CHB, whereas no significant predictor was identified in those with CHC. CONCLUSION: After comparison of patients who had more than 10 valid measurements for LSM, three VMs may be enough to assess liver fibrosis using LSM without significant loss of accuracy in patients with CHC and patients with CHB. However, ALT should be considered when interpreting LSM for patients with CHB.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfYONSEI MEDICAL JOURNAL-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAlanine Transaminase/metabolism-
dc.subject.MESHFemale-
dc.subject.MESHHepatitis B, Chronic/complications*-
dc.subject.MESHHepatitis B, Chronic/metabolism-
dc.subject.MESHHumans-
dc.subject.MESHLiver/metabolism-
dc.subject.MESHLiver/pathology-
dc.subject.MESHLiver Cirrhosis/diagnosis*-
dc.subject.MESHLiver Cirrhosis/etiology-
dc.subject.MESHLiver Cirrhosis/metabolism-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHProspective Studies-
dc.titleHow many valid measurements are necessary to assess liver fibrosis using FibroScan® in patients with chronic viral hepatitis? An analysis of subjects with at least 10 valid measurements-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Pathology (병리학)-
dc.contributor.googleauthorHui Won Jang-
dc.contributor.googleauthorSeung Up Kim-
dc.contributor.googleauthorJun Yong Park-
dc.contributor.googleauthorSang Hoon Ahn-
dc.contributor.googleauthorKwang-Hyub Han-
dc.contributor.googleauthorChae Yoon Chon-
dc.contributor.googleauthorYoung Nyun Park-
dc.contributor.googleauthorEun Hee Choi-
dc.contributor.googleauthorDo Young Kim-
dc.identifier.doi22318821-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA02226-
dc.contributor.localIdA03499-
dc.contributor.localIdA04268-
dc.contributor.localIdA00654-
dc.contributor.localIdA01563-
dc.contributor.localIdA01675-
dc.contributor.localIdA03544-
dc.contributor.localIdA00385-
dc.relation.journalcodeJ02813-
dc.identifier.eissn1976-2437-
dc.identifier.pmid22318821-
dc.subject.keywordChronic viral hepatitis-
dc.subject.keywordchronic hepatitis B-
dc.subject.keywordchronic hepatitis C-
dc.subject.keywordfibroscan-
dc.subject.keywordliver stiffness measurement-
dc.subject.keywordtransient elastography-
dc.contributor.alternativeNameAhn, Sang Hoon-
dc.contributor.alternativeNameJang, Hui Won-
dc.contributor.alternativeNameChon, Chae Yoon-
dc.contributor.alternativeNameHan, Kwang Hyup-
dc.contributor.alternativeNameKim, Do Young-
dc.contributor.alternativeNameKim, Seung Up-
dc.contributor.alternativeNamePark, Young Nyun-
dc.contributor.alternativeNamePark, Jun Yong-
dc.contributor.affiliatedAuthorAhn, Sang Hoon-
dc.contributor.affiliatedAuthorJang, Hui Won-
dc.contributor.affiliatedAuthorHan, Kwang Hyup-
dc.contributor.affiliatedAuthorKim, Seung Up-
dc.contributor.affiliatedAuthorPark, Young Nyun-
dc.contributor.affiliatedAuthorPark, Jun Yong-
dc.contributor.affiliatedAuthorChon, Chae Yoon-
dc.contributor.affiliatedAuthorKim, Do Young-
dc.citation.volume53-
dc.citation.number2-
dc.citation.startPage337-
dc.citation.endPage345-
dc.identifier.bibliographicCitationYONSEI MEDICAL JOURNAL, Vol.53(2) : 337-345, 2012-
dc.identifier.rimsid29630-
dc.type.rimsART-
Appears in Collections:
6. Others (기타) > Dept. of Health Promotion (건강의학과) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers

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