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Cited 2 times in

Endotoxin is not essential for the development of cockroach induced allergic airway inflammation

DC FieldValueLanguage
dc.contributor.author박중원-
dc.contributor.author손정호-
dc.contributor.author신유섭-
dc.contributor.author이재현-
dc.contributor.author홍천수-
dc.date.accessioned2014-12-19T17:48:31Z-
dc.date.available2014-12-19T17:48:31Z-
dc.date.issued2012-
dc.identifier.issn0513-5796-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/92098-
dc.description.abstractPURPOSE: Cockroach (CR) is an important inhalant allergen and can induce allergic asthma. However, the mechanism by which CR induces airway allergic inflammation and the role of endotoxin in CR extract are not clearly understood in regards to the development of airway inflammation. In this study, we evaluated whether endotoxin is essential to the development of CR induced airway allergic inflammation in mice. MATERIALS AND METHODS: Airway allergic inflammation was induced by intranasal administration of either CR extract, CR with additional endotoxin, or endotoxin depleted CR extract, respectively, in BALB/c wild type mice. CR induced inflammation was also evaluated with toll like receptor-4 (TLR-4) mutant (C3H/HeJ) and wild type (C3H/HeN) mice. RESULTS: Intranasal administration of CR extracts significantly induced airway hyperresponsiveness (AHR), eosinophilic and neutrophilic airway inflammation, as well as goblet cell hyperplasia in a dose-dependent manner. The addition of endotoxin along with CR allergen attenuated eosinophilic inflammation, interleukin (IL)-13 level, and goblet cell hyperplasia of respiratory epithelium; however, it did not affect the development of AHR. Endotoxin depletion in CR extract did not attenuate eosinophilic inflammation and lymphocytosis in BAL fluid, AHR and IL-13 expression in the lungs compared to CR alone. The attenuation of AHR, eosinophilic inflammation, and goblet cell hyperplasia induced by CR extract alone was not different between TLR-4 mutant and the wild type mice. In addition, heat inactivated CR extract administration induced attenuated AHR and eosinophilic inflammation. CONCLUSION: Endotoxin in CR extracts may not be essential to the development of airway inflammation.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfYonsei Medical Journal-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleEndotoxin is not essential for the development of cockroach induced allergic airway inflammation-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentYonsei Biomedical Research Center (연세의생명연구원)-
dc.contributor.googleauthorYoo Seob Shin-
dc.contributor.googleauthorJung-Ho Sohn-
dc.contributor.googleauthorJoo-Young Kim-
dc.contributor.googleauthorJae Hyun Lee-
dc.contributor.googleauthorSang-Heon Cho-
dc.contributor.googleauthorSoo-Jong Hong-
dc.contributor.googleauthorJoo-Shil Lee-
dc.contributor.googleauthorChein-Soo Hong-
dc.contributor.googleauthorJung-Won Park-
dc.identifier.doi10.3349/ymj.2012.53.3.593-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01681-
dc.contributor.localIdA01993-
dc.contributor.localIdA03086-
dc.contributor.localIdA02130-
dc.contributor.localIdA04448-1-
dc.relation.journalcodeJ02813-
dc.contributor.alternativeNamePark, Jung Won-
dc.contributor.alternativeNameSohn, Jung Ho-
dc.contributor.alternativeNameShin, Yoo Seob-
dc.contributor.alternativeNameLee, Jae Hyun-
dc.contributor.alternativeNameHong, Chein Soo-
dc.contributor.affiliatedAuthorPark, Jung Won-
dc.contributor.affiliatedAuthorSohn, Jung Ho-
dc.contributor.affiliatedAuthorLee, Jae Hyun-
dc.contributor.affiliatedAuthorShin, Yoo Seob-
dc.contributor.affiliatedAuthorHong, Chein Soo-
dc.citation.volume53-
dc.citation.number3-
dc.citation.startPage593-
dc.citation.endPage602-
dc.identifier.bibliographicCitationYonsei Medical Journal, Vol.53(3) : 593-602, 2012-
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)

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