122 322

Cited 0 times in

Correlations between coronary plaque tissue composition assessed by virtual histology and blood levels of biomarkers for coronary artery disease

DC FieldValueLanguage
dc.contributor.author최동훈-
dc.contributor.author홍명기-
dc.contributor.author고영국-
dc.contributor.author김병극-
dc.contributor.author김보현-
dc.contributor.author김중선-
dc.contributor.author신동호-
dc.contributor.author장양수-
dc.date.accessioned2014-12-19T17:47:57Z-
dc.date.available2014-12-19T17:47:57Z-
dc.date.issued2012-
dc.identifier.issn0513-5796-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/92080-
dc.description.abstractPURPOSE: We investigated correlations of coronary plaque composition determined by virtual histology (VH) intravascular ultrasound (IVUS) and blood levels of biomarkers that represent the vulnerability of coronary plaques. MATERIALS AND METHODS: Pre- and postprocedural blood levels of high sensitivity C-reactive protein, soluble CD40 ligand (sCD40L), matrix metalloproteinase-9, and neopterin were measured in 70 patients with stable angina (SA) or unstable angina (UA) who were undergoing percutaneous coronary intervention (PCI) for single lesions. We evaluated the data for correlations between these biomarkers and necrotic core contents in PCI target lesions analyzed by VH. RESULTS: Clinical characteristics, IVUS, VH, and biomarker blood levels were not different between the SA and the UA group except for more frequent previous statin use (52.3% vs. 23.1%, p=0.017) and lower remodeling index in the SA group (0.98±0.09 vs. 1.10±0.070, p<0.001). Among the biomarkers evaluated, only pre-PCI neopterin level showed a weakly significant correlation with the absolute volume of the necrotic core (r=0.320, p=0.008). Pre- and post-PCI blood levels of sCD40L (r=0.220, p=0.072; r=0.231, p=0.062) and post-PCI blood level of neopterin (r=0.238, p=0.051) showed trends toward weakly positive correlations with the absolute volume of necrotic core. CONCLUSION: We found a weakly positive correlation between the pre-PCI neopterin level and necrotic core volume in the PCI-target lesion. The clinical implications of our findings need to be investigated in further studies.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfYONSEI MEDICAL JOURNAL-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAged-
dc.subject.MESHAngina Pectoris/blood-
dc.subject.MESHAngina, Stable/blood-
dc.subject.MESHAngina, Unstable/blood-
dc.subject.MESHAngioplasty, Balloon, Coronary-
dc.subject.MESHBiomarkers/blood-
dc.subject.MESHC-Reactive Protein/metabolism-
dc.subject.MESHCD40 Ligand/blood-
dc.subject.MESHCoronary Artery Disease/blood*-
dc.subject.MESHCoronary Artery Disease/diagnostic imaging-
dc.subject.MESHCoronary Artery Disease/metabolism*-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMatrix Metalloproteinase 9/blood-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNeopterin/blood-
dc.subject.MESHPlaque, Atherosclerotic/blood*-
dc.subject.MESHPlaque, Atherosclerotic/diagnostic imaging-
dc.subject.MESHPlaque, Atherosclerotic/metabolism*-
dc.subject.MESHUltrasonography, Interventional-
dc.titleCorrelations between coronary plaque tissue composition assessed by virtual histology and blood levels of biomarkers for coronary artery disease-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentYonsei Biomedical Research Center (연세의생명연구원)-
dc.contributor.googleauthorYoung-Guk Ko-
dc.contributor.googleauthorVan Cuong Le-
dc.contributor.googleauthorBo Hyun Kim-
dc.contributor.googleauthorDong-Ho Shin-
dc.contributor.googleauthorJung-Sun Kim-
dc.contributor.googleauthorByeong-Keuk Kim-
dc.contributor.googleauthorDonghoon Choi-
dc.contributor.googleauthorYangsoo Jang-
dc.contributor.googleauthorMyeong-Ki Hong-
dc.identifier.doi22476993-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA04053-
dc.contributor.localIdA04391-
dc.contributor.localIdA00127-
dc.contributor.localIdA00493-
dc.contributor.localIdA00513-
dc.contributor.localIdA00961-
dc.contributor.localIdA02097-
dc.contributor.localIdA03448-
dc.relation.journalcodeJ02813-
dc.identifier.eissn1976-2437-
dc.identifier.pmid22476993-
dc.subject.keywordAtherosclerosis-
dc.subject.keywordcoronary artery disease-
dc.subject.keywordinflammation-
dc.subject.keywordintravascular ultrasound-
dc.contributor.alternativeNameChoi, Dong Hoon-
dc.contributor.alternativeNameHong, Myeong Ki-
dc.contributor.alternativeNameKo, Young Guk-
dc.contributor.alternativeNameKim, Byeong Keuk-
dc.contributor.alternativeNameKim, Bo Hyun-
dc.contributor.alternativeNameKim, Jung Sun-
dc.contributor.alternativeNameShin, Dong Ho-
dc.contributor.alternativeNameJang, Yang Soo-
dc.contributor.affiliatedAuthorChoi, Dong Hoon-
dc.contributor.affiliatedAuthorHong, Myeong Ki-
dc.contributor.affiliatedAuthorKo, Young Guk-
dc.contributor.affiliatedAuthorKim, Byeong Keuk-
dc.contributor.affiliatedAuthorKim, Bo Hyun-
dc.contributor.affiliatedAuthorKim, Jung Sun-
dc.contributor.affiliatedAuthorShin, Dong Ho-
dc.contributor.affiliatedAuthorJang, Yang Soo-
dc.citation.volume53-
dc.citation.number3-
dc.citation.startPage508-
dc.citation.endPage516-
dc.identifier.bibliographicCitationYONSEI MEDICAL JOURNAL, Vol.53(3) : 508-516, 2012-
Appears in Collections:
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.