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Elevated serum C-reactive protein as a prognostic marker in small cell lung cancer

 Soojung Hong  ;  Young Ae Kang  ;  Byoung Chul Cho  ;  Dae Joon Kim 
 YONSEI MEDICAL JOURNAL, Vol.53(1) : 111-117, 2012 
Journal Title
Issue Date
Aged ; Aged, 80 and over ; Biomarkers/blood ; C-Reactive Protein/metabolism* ; Female ; Humans ; Kaplan-Meier Estimate ; Lung Neoplasms/blood* ; Lung Neoplasms/mortality* ; Male ; Middle Aged ; Predictive Value of Tests ; Prognosis ; Small Cell Lung Carcinoma/blood* ; Small Cell Lung Carcinoma/mortality*
C-reactive protein ; prognosis ; small cell lung cancer
PURPOSE: Elevated C-reactive protein (CRP) is associated with poor prognosis in several tumor types. The purpose of this study was to investigate serum CRP as a prognostic marker in small cell lung cancer (SCLC). MATERIALS AND METHODS: The pretreatment serum CRP level was measured in 157 newly diagnosed SCLC patients, and correlation between serum CRP level and other clinical parameters was analyzed. Multivariate analyses were performed to find prognostic markers using Cox's proportional hazards model. RESULTS: The initial CRP concentration was within the normal range in 72 (45.9%) patients and elevated in 85 (54.1%) patients. There was a significant correlation between serum CRP level and the extent of disease (p<0.001), weight loss (p=0.029) and chest radiation (p=0.001). Median overall survival (OS) in the normal CRP group was significantly longer than with the high CRP group (22.5 months vs. 11.2 months, p<0.001). Extent of disease (p<0.001), age (p=0.025), and performance status (p<0.001) were additional prognostic factors on univariate analysis. On multivariate analysis, elevated serum CRP level was an independent prognostic factor for poor survival (HR=1.8; p=0.014), regardless of the extent of disease (HR=3.7; p<0.001) and performance status (HR=2.2; p<0.001). CONCLUSION: High level of CRP was an independent poor prognostic serum marker in addition to previously well-known prognosticators in patients with SCLC.
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1. College of Medicine (의과대학) > Dept. of Thoracic and Cardiovascular Surgery (흉부외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Young Ae(강영애) ORCID logo https://orcid.org/0000-0002-7783-5271
Kim, Dae Joon(김대준)
Cho, Byoung Chul(조병철) ORCID logo https://orcid.org/0000-0002-5562-270X
Hong, Soo Jung(홍수정)
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