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Hepatocellular carcinoma in Budd-Chiari syndrome: a single center experience with long-term follow-up in South Korea

Authors
 Hana Park  ;  Jin Young Yoon  ;  Kyeong Hye Park  ;  Do Young Kim  ;  Sang Hoon Ahn  ;  Kwang-Hyub Han  ;  Chae Yoon Chon  ;  Jun Yong Park 
Citation
 World Journal of Gastroenterology, Vol.18(16) : 1946-1952, 2012 
Journal Title
 World Journal of Gastroenterology 
ISSN
 1007-9327 
Issue Date
2012
Abstract
AIM: To evaluate long-term clinical course of Budd-Chiari syndrome (BCS) and predictive factors associated with the development of hepatocellular carcinoma (HCC) and survival. METHODS: We analyzed 67 patients with BCS between June 1988 and May 2008. The diagnosis of BCS was confirmed by hepatic venous outflow obstruction shown on abdominal ultrasound sonography, computed tomography, magnetic resonance imaging, or venography. The median follow-up period was 103 ± 156 [interquartile range (IQR)] mo. RESULTS: The median age of the patients was 47 ± 16 (IQR) years. At diagnosis, 54 patients had cirrhosis, 25 (37.3%) Child-Pugh class A, 23 (34.3%) Child-Pugh class B, and six (9.0%) patients Child-Pugh class C. During the follow-up period, HCC was developed in 17 patients, and the annual incidence of HCC in patients with BCS was 2.8%. Patients in HCC group (n = 17) had higher hepatic venous pressure gradient (HVPG) than those in non-HCC group (n = 50) (21 ± 12 mmHg vs 14 ± 7 mmHg, P = 0.019). The survival rate of BCS patients was 86.2% for 5 years, 73.8% for 10 years, and 61.2% for 15 years. In patients with BCS and HCC, survival was 79% for 5 years, 43.1% for 10 years, and 21.5% for 15 years. CONCLUSION: The incidence of HCC in patients with BCS was similar to that in patients with other etiologic cirrhosis in South Korea. The HVPG is expected to provide additional information for predicting HCC development in BCS patients.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/92016
Files in This Item:
T201201162.pdf Download
DOI
10.3748/wjg.v18.i16.1946
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
Yonsei Authors
김도영(Kim, Do Young)
박경혜(Park, Kyeong Hye)
박준용(Park, Jun Yong) ORCID logo https://orcid.org/0000-0001-6324-2224
박하나(Park, Ha Na)
안상훈(Ahn, Sang Hoon)
전재윤(Chon, Chae Yoon)
한광협(Han, Kwang Hyup)
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