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Significance of high-normal serum uric acid level as a risk factor for arterial stiffness in healthy Korean men
DC Field | Value | Language |
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dc.contributor.author | 이혜리 | - |
dc.contributor.author | 신진영 | - |
dc.contributor.author | 심재용 | - |
dc.date.accessioned | 2014-12-19T17:45:37Z | - |
dc.date.available | 2014-12-19T17:45:37Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 1358-863X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/92004 | - |
dc.description.abstract | A high serum uric acid (SUA) level is a known risk factor for cardiovascular disease. However, little is known about the relationship between arterial stiffness and uric acid in healthy subjects with a normal SUA level. We assessed whether a high-normal uric acid level increased arterial stiffness by measuring brachial-ankle pulse wave velocity (ba-PWV) in healthy subjects. Among 779 subjects who visited the health promotion center, 393 men and 234 women with normal SUA levels (male: 3.5-8.0 mg/dl, female: 2.5-5.4 mg/dl) were divided into quartiles: in men, Q1 (n = 90, 3.5-4.3 mg/dl), Q2 (n = 94, 4.4-5.1 mg/dl), Q3 (n = 106, 5.2-5.9 mg/dl) and Q4 (n = 103, 6.0-8.0 mg/dl); in women, Q1 (n = 57, 2.5-3.6 mg/dl), Q2 (n = 49, 3.7-4.1 mg/dl), Q3 (n = 61, 4.2-4.6 mg/dl) and Q4 (n = 67, 4.7-5.4 mg/dl). The mean values of ba-PWV increased gradually by SUA quartile. The men's SUA had an independent, positive association with ba-PWV after correcting for age, glucose, body mass index, blood pressure, resting heart rate, high-sensitivity C-reactive protein (hs-CRP), high-density lipoprotein (HDL)-cholesterol and triglyceride (R (2) = 0.39, adjusted R (2) = 0.37, p < 0.001). The odds ratios (95% CI) for high ba-PWVs (> 75th percentile, 1473 cm/s) in men were 1.89 (0.69-5.20, Q2), 2.36 (1.10-5.08, Q3), and 2.91 (1.39-6.11, Q4), after adjusting for confounding factors (p < 0.001). In women, SUA showed no independent association with ba-PWV (p = 0.186). After adjusting for confounding factors, the mean ba-PWV values of Q3 (1418 cm/s) and Q4 (1421 cm/s) in men were higher than those of Q1 (1355 cm/s) (p < 0.05). Above the SUA level of 5.2 mg/dl, arterial stiffness was increased in healthy Korean men. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | VASCULAR MEDICINE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Asian Continental Ancestry Group | - |
dc.subject.MESH | C-Reactive Protein/analysis* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Odds Ratio | - |
dc.subject.MESH | Reference Values | - |
dc.subject.MESH | Risk Factors | - |
dc.subject.MESH | Sex Factors | - |
dc.subject.MESH | Uric Acid/blood* | - |
dc.subject.MESH | Vascular Stiffness/physiology* | - |
dc.title | Significance of high-normal serum uric acid level as a risk factor for arterial stiffness in healthy Korean men | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Family Medicine (가정의학) | - |
dc.contributor.googleauthor | Jin Young Shin | - |
dc.contributor.googleauthor | Hye Ree Lee | - |
dc.contributor.googleauthor | Jae Yong Shim | - |
dc.identifier.doi | 22363017 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02207 | - |
dc.contributor.localId | A03310 | - |
dc.contributor.localId | A02165 | - |
dc.relation.journalcode | J02778 | - |
dc.identifier.eissn | 1477-0377 | - |
dc.identifier.pmid | 22363017 | - |
dc.identifier.url | http://vmj.sagepub.com/content/17/1/37.long | - |
dc.subject.keyword | arterial stiffness | - |
dc.subject.keyword | brachial–ankle pulse wave velocity | - |
dc.subject.keyword | serum uric acid | - |
dc.contributor.alternativeName | Lee, Hye Ree | - |
dc.contributor.alternativeName | Shin, Jin Young | - |
dc.contributor.alternativeName | Shim, Jae Yong | - |
dc.contributor.affiliatedAuthor | Shim, Jae Yong | - |
dc.contributor.affiliatedAuthor | Lee, Hye Ree | - |
dc.contributor.affiliatedAuthor | Shin, Jin Young | - |
dc.citation.volume | 17 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 37 | - |
dc.citation.endPage | 43 | - |
dc.identifier.bibliographicCitation | VASCULAR MEDICINE, Vol.17(1) : 37-43, 2012 | - |
dc.identifier.rimsid | 30065 | - |
dc.type.rims | ART | - |
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