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Significance of high-normal serum uric acid level as a risk factor for arterial stiffness in healthy Korean men

DC FieldValueLanguage
dc.contributor.author이혜리-
dc.contributor.author신진영-
dc.contributor.author심재용-
dc.date.accessioned2014-12-19T17:45:37Z-
dc.date.available2014-12-19T17:45:37Z-
dc.date.issued2012-
dc.identifier.issn1358-863X-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/92004-
dc.description.abstractA high serum uric acid (SUA) level is a known risk factor for cardiovascular disease. However, little is known about the relationship between arterial stiffness and uric acid in healthy subjects with a normal SUA level. We assessed whether a high-normal uric acid level increased arterial stiffness by measuring brachial-ankle pulse wave velocity (ba-PWV) in healthy subjects. Among 779 subjects who visited the health promotion center, 393 men and 234 women with normal SUA levels (male: 3.5-8.0 mg/dl, female: 2.5-5.4 mg/dl) were divided into quartiles: in men, Q1 (n = 90, 3.5-4.3 mg/dl), Q2 (n = 94, 4.4-5.1 mg/dl), Q3 (n = 106, 5.2-5.9 mg/dl) and Q4 (n = 103, 6.0-8.0 mg/dl); in women, Q1 (n = 57, 2.5-3.6 mg/dl), Q2 (n = 49, 3.7-4.1 mg/dl), Q3 (n = 61, 4.2-4.6 mg/dl) and Q4 (n = 67, 4.7-5.4 mg/dl). The mean values of ba-PWV increased gradually by SUA quartile. The men's SUA had an independent, positive association with ba-PWV after correcting for age, glucose, body mass index, blood pressure, resting heart rate, high-sensitivity C-reactive protein (hs-CRP), high-density lipoprotein (HDL)-cholesterol and triglyceride (R (2) = 0.39, adjusted R (2) = 0.37, p < 0.001). The odds ratios (95% CI) for high ba-PWVs (> 75th percentile, 1473 cm/s) in men were 1.89 (0.69-5.20, Q2), 2.36 (1.10-5.08, Q3), and 2.91 (1.39-6.11, Q4), after adjusting for confounding factors (p < 0.001). In women, SUA showed no independent association with ba-PWV (p = 0.186). After adjusting for confounding factors, the mean ba-PWV values of Q3 (1418 cm/s) and Q4 (1421 cm/s) in men were higher than those of Q1 (1355 cm/s) (p < 0.05). Above the SUA level of 5.2 mg/dl, arterial stiffness was increased in healthy Korean men.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfVascular Medicine-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleSignificance of high-normal serum uric acid level as a risk factor for arterial stiffness in healthy Korean men-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Family Medicine (가정의학)-
dc.contributor.googleauthorJin Young Shin-
dc.contributor.googleauthorHye Ree Lee-
dc.contributor.googleauthorJae Yong Shim-
dc.identifier.doi10.1177/1358863X11434197-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA02207-
dc.contributor.localIdA03310-
dc.contributor.localIdA02165-
dc.relation.journalcodeJ02778-
dc.identifier.urlhttp://vmj.sagepub.com/content/17/1/37.long-
dc.contributor.alternativeNameLee, Hye Ree-
dc.contributor.alternativeNameShin, Jin Young-
dc.contributor.alternativeNameShim, Jae Yong-
dc.contributor.affiliatedAuthorShim, Jae Yong-
dc.contributor.affiliatedAuthorLee, Hye Ree-
dc.contributor.affiliatedAuthorShin, Jin Young-
dc.citation.volume17-
dc.citation.number1-
dc.citation.startPage37-
dc.citation.endPage43-
dc.identifier.bibliographicCitationVascular Medicine, Vol.17(1) : 37-43, 2012-
dc.description.scptc20-
dc.date.scptcdate2018-12-23-
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Family Medicine (가정의학교실)

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