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Demonstration of safety and enhanced seroprotection against hepatitis B with investigational HBsAg-1018 ISS vaccine compared to a licensed hepatitis B vaccine

Authors
 Benjamin P. Sablan  ;  Dong Joon Kim  ;  Nina G. Barzaga  ;  Wan Cheng Chow  ;  Mong Cho  ;  Sang Hoon Ahn  ;  Seong Gyu Hwang  ;  JiHyun Lee  ;  Hamid Namini  ;  William L. Heyward 
Citation
 VACCINE, Vol.30(16) : 2689-2696, 2012 
Journal Title
 VACCINE 
ISSN
 0264-410X 
Issue Date
2012
MeSH
Adjuvants, Immunologic ; Adult ; Aged ; Antibodies, Viral/blood ; Antibodies, Viral/immunology ; Double-Blind Method ; Drug-Related Side Effects and Adverse Reactions ; Female ; Hepatitis B/immunology ; Hepatitis B/prevention & control* ; Hepatitis B/virology ; Hepatitis B Surface Antigens/genetics ; Hepatitis B Surface Antigens/immunology ; Hepatitis B Vaccines/adverse effects ; Hepatitis B Vaccines/genetics ; Hepatitis B Vaccines/immunology* ; Hepatitis B virus/immunology* ; Humans ; Immunity, Humoral ; Male ; Middle Aged ; Oligodeoxyribonucleotides/genetics ; Oligodeoxyribonucleotides/immunology ; Placebos ; Toll-Like Receptor 9/agonists ; Toll-Like Receptor 9/genetics ; Toll-Like Receptor 9/immunology
Keywords
Hepatitis B vaccine ; Seroprotection ; Older adults
Abstract
Adults 40 years of age and older have been shown to be hypo-responsive immunologically to the currently available hepatitis B virus (HBV) vaccines. Three intramuscular doses of a Toll-like receptor 9 agonist, 1018 immunostimulatory sequence (1018 ISS) adjuvant, combined with recombinant hepatitis B surface antigen (HBsAg) demonstrated faster, superior, and more durable seroprotection than three doses of a licensed comparator HBV vaccine (Engerix-B(®)). This investigational vaccine, HBsAg-1018 ISS, was well tolerated with a safety profile similar to the comparator vaccine. These results suggest that HBsAg-1018 may be more effective in this hypo-responsive population
Full Text
http://www.sciencedirect.com/science/article/pii/S0264410X1200165X
DOI
22342916
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Ahn, Sang Hoon(안상훈) ORCID logo https://orcid.org/0000-0002-3629-4624
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/92001
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