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Donor evaluation for lung transplantation in Korea

Authors
 H.C. Paik  ;  S.J. Haam  ;  D.Y. Lee  ;  G.J. Yi  ;  S.W. Song  ;  Y.T. Kim  ;  C.H. Kang  ;  K.M. Kim  ;  S.I. Park  ;  S.H. Jheon 
Citation
 TRANSPLANTATION PROCEEDINGS, Vol.44(4) : 870-874, 2012 
Journal Title
 TRANSPLANTATION PROCEEDINGS 
ISSN
 0041-1345 
Issue Date
2012
MeSH
Adolescent ; Adult ; Aged ; Child ; Donor Selection* ; Female ; Humans ; Lung Diseases/mortality ; Lung Diseases/surgery* ; Lung Transplantation*/adverse effects ; Lung Transplantation*/mortality ; Male ; Middle Aged ; Republic of Korea ; Retrospective Studies ; Risk Assessment ; Risk Factors ; Time Factors ; Tissue Donors/supply & distribution* ; Treatment Outcome ; Waiting Lists/mortality ; Young Adult
Keywords
Adolescent ; Adult ; Aged ; Child ; Donor Selection* ; Female ; Humans ; Lung Diseases/mortality ; Lung Diseases/surgery* ; Lung Transplantation*/adverse effects ; Lung Transplantation*/mortality ; Male ; Middle Aged ; Republic of Korea ; Retrospective Studies ; Risk Assessment ; Risk Factors ; Time Factors ; Tissue Donors/supply & distribution* ; Treatment Outcome ; Waiting Lists/mortality ; Young Adult
Abstract
Lung transplantation for end-stage lung disease results in prolonged survival and improved pulmonary function. However, the shortage of donor lungs has been a major limiting factor in Korea. We sought to investigate the number and utilization of donor lungs by the five institutions performing LTx in Korea, retrospectively reviewing outcomes of organs registered in the Korean Network for Organ Sharing from January to December, 2010. Lungs were offered from 270 brain-dead patients (189 males and 81 females) of mean age of 45.2 ± 14.2 years (range, 12 to 77 years). The most common cause of brain death was hemorrhage (n = 219, 81%). Only 18 (6.7%) donor lungs were used, which was low compared with kidney (93.3%), liver (86.3%), heart (26.7%), and pancreas (11.1%) use. The mean age of donors of transplanted lungs was 35.7 years (range, 14 to 51 years) compared with 45.9 years for other organs (P = .003). The characteristics of utilized donor lungs were: mean partial pressure of oxygen (PaO(2)), 300.9 mm Hg; mean smoking history, as 2.7 pack-years; and mean body mass index, 21.2 kg/m(2). The causes of refusal were medical ineligibility (n = 129) including poor PaO(2), abnormal chest x-ray, long smoking history, older age (n = 46), no properly matched recipient (n = 46), unknown (n = 17), and family withdrawal (n = 14). Only 8 (33.3%) were transplanted from standard criteria and 10 from the lungs that did not satisfy these criteria. An efficient utilization system is needed to improve lung transplantations.
Full Text
http://www.sciencedirect.com/science/article/pii/S0041134511017222
DOI
22564570
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Thoracic and Cardiovascular Surgery (흉부외과학교실) > 1. Journal Papers
Yonsei Authors
Paik, Hyo Chae(백효채) ORCID logo https://orcid.org/0000-0001-9309-8235
Song, Suk Won(송석원) ORCID logo https://orcid.org/0000-0002-9850-9707
Yi, Gi Jong(이기종)
Lee, Doo Yun(이두연)
Haam, Seok Jin(함석진)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/91963
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