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The fate of patients on the waiting list for lung transplantation in Korea

Authors
 H.C. Paik  ;  S.J. Haam  ;  D.Y. Lee  ;  G.J. Yi  ;  S.W. Song  ;  Y.T. Kim  ;  C.H. Kang  ;  K.M. Kim  ;  S.I. Park  ;  S.H. Jheon 
Citation
 TRANSPLANTATION PROCEEDINGS, Vol.44(4) : 865-869, 2012 
Journal Title
 TRANSPLANTATION PROCEEDINGS 
ISSN
 0041-1345 
Issue Date
2012
MeSH
Adolescent ; Adult ; Aged ; Cause of Death ; Child ; Child, Preschool ; Female ; Humans ; Lung Diseases/mortality* ; Lung Diseases/surgery* ; Lung Transplantation*/adverse effects ; Lung Transplantation*/mortality ; Male ; Middle Aged ; Prognosis ; Referral and Consultation ; Registries ; Republic of Korea/epidemiology ; Retrospective Studies ; Risk Assessment ; Risk Factors ; Survival Analysis ; Time Factors ; Tissue Donors/supply & distribution* ; Waiting Lists/mortality* ; Young Adult
Keywords
Adolescent ; Adult ; Aged ; Cause of Death ; Child ; Child, Preschool ; Female ; Humans ; Lung Diseases/mortality* ; Lung Diseases/surgery* ; Lung Transplantation*/adverse effects ; Lung Transplantation*/mortality ; Male ; Middle Aged ; Prognosis ; Referral and Consultation ; Registries ; Republic of Korea/epidemiology ; Retrospective Studies ; Risk Assessment ; Risk Factors ; Survival Analysis ; Time Factors ; Tissue Donors/supply & distribution* ; Waiting Lists/mortality* ; Young Adult
Abstract
Lung transplantation for end-stage lung disease results in prolonged actuarial survival and improved pulmonary function. However, the shortage of donor lungs has been a major limiting factor in transplantation. The purpose of this study was to analyze the waiting time and mortality rate for each disease entity. The medical records of all patients listed in The Korean Network for Organ Sharing (KONOS) from May 1996 to May 2011 were analyzed to identify waiting times and causes of death. During the study period, 146 patients (86 males and 60 females) of mean age of 46.6 years (range; 5 to 73 years) showed idiopathic pulmonary fibrosis (IPF; n = 61), chronic obstructive pulmonary disease (COPD; n = 19) or bronchiectasis (n = 15). Sixty-five patients (44.5%) underwent lung or heart-lung transplantation. Sixty-two patients (42.5%) expired during the waiting period, and 19 patients are still on the waiting list. The mortality rate while waiting was highest among patients with primary pulmonary hypertension (62.5%) followed by IPF (57.4%), and acute respiratory distress syndrome (ARDS) (55.6%). The mean time from diagnosis to registration in KONOS was 15.5 months among the expired and 13.2 months in the transplanted group (P = .455). The mean time on waiting list was 8.2 months in the expired group and 3.7 months in the transplanted group (P = .012). In the expired group, the mean survival time was significantly shorter among patients with ARDS (2.2 months, P = .004) compared to IPF (7.9 months), COPD (10.7 months), and primary pulmonary hypertension (PPH) (30.0 months). The high mortality rate (42.5%) during the waiting period in Korea may result from the lack of donors and the delay in registration.
Full Text
http://www.sciencedirect.com/science/article/pii/S0041134511017210
DOI
22564569
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Thoracic and Cardiovascular Surgery (흉부외과학교실) > 1. Journal Papers
Yonsei Authors
Paik, Hyo Chae(백효채) ORCID logo https://orcid.org/0000-0001-9309-8235
Song, Suk Won(송석원) ORCID logo https://orcid.org/0000-0002-9850-9707
Yi, Gi Jong(이기종)
Lee, Doo Yun(이두연)
Haam, Seok Jin(함석진)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/91962
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