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Accompanying renal injuries did not impact graft survival in patients with transplant glomerulopathy

Authors
 B.J. Lim  ;  D.J. Joo  ;  Y.S. Kim  ;  H.J. Jeong 
Citation
 TRANSPLANTATION PROCEEDINGS, Vol.44(3) : 616-618, 2012 
Journal Title
 TRANSPLANTATION PROCEEDINGS 
ISSN
 0041-1345 
Issue Date
2012
MeSH
Glomerulonephritis/etiology* ; Glomerulonephritis/physiopathology ; Graft Survival* ; Humans ; Kidney Transplantation/adverse effects* ; Retrospective Studies
Keywords
Glomerulonephritis/etiology* ; Glomerulonephritis/physiopathology ; Graft Survival* ; Humans ; Kidney Transplantation/adverse effects* ; Retrospective Studies
Abstract
Transplant glomerulopathy (TG) a morphological feature of chronic active antibody-mediated rejection, is associated with donor-specific antibody, peritubular capillary deposition of C4d, and multilayering of peritubular capillary basement membranes. To evaluate the significance of accompanying nonimmunologic injuries in TG, we retrospectively reviewed 2839 renal allograft cases at our institute among which TG was diagnosed in 81 patients (2.9%). Among TG cases, 48 samples showed accompanying diseases such as chronic calcineurin inhibitor toxicity, hepatitis viral infection, posttransplant diabetes, and glomerulonephritis. Comparing the pure form of TG with TG-mixed diseases, there was no difference in patient demography, serum creatinine values, and proteinuria. Among histological parameters, severe hyalinosis was more frequently observed among the TG plus other diseases group. The two groups did not show significant difference in graft survival (P = .216).
Full Text
http://www.sciencedirect.com/science/article/pii/S0041134511017040
DOI
22483451
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Yu Seun(김유선) ORCID logo https://orcid.org/0000-0002-5105-1567
Lim, Beom Jin(임범진) ORCID logo https://orcid.org/0000-0003-2856-0133
Jeong, Hyeon Joo(정현주) ORCID logo https://orcid.org/0000-0002-9695-1227
Joo, Dong Jin(주동진) ORCID logo https://orcid.org/0000-0001-8405-1531
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/91957
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