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Accompanying renal injuries did not impact graft survival in patients with transplant glomerulopathy

Authors
 B.J. Lim  ;  D.J. Joo  ;  Y.S. Kim  ;  H.J. Jeong 
Citation
 Transplantation Proceedings, Vol.44(3) : 616-618, 2012 
Journal Title
 Transplantation Proceedings 
ISSN
 0041-1345 
Issue Date
2012
Abstract
Transplant glomerulopathy (TG) a morphological feature of chronic active antibody-mediated rejection, is associated with donor-specific antibody, peritubular capillary deposition of C4d, and multilayering of peritubular capillary basement membranes. To evaluate the significance of accompanying nonimmunologic injuries in TG, we retrospectively reviewed 2839 renal allograft cases at our institute among which TG was diagnosed in 81 patients (2.9%). Among TG cases, 48 samples showed accompanying diseases such as chronic calcineurin inhibitor toxicity, hepatitis viral infection, posttransplant diabetes, and glomerulonephritis. Comparing the pure form of TG with TG-mixed diseases, there was no difference in patient demography, serum creatinine values, and proteinuria. Among histological parameters, severe hyalinosis was more frequently observed among the TG plus other diseases group. The two groups did not show significant difference in graft survival (P = .216).
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/91957
DOI
10.1016/j.transproceed.2011.12.042
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실)
Yonsei Authors
김유선(Kim, Yu Seun) ; 임범진(Lim, Beom Jin) ; 정현주(Jeong, Hyeon Joo) ; 주동진(Joo, Dong Jin)
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Full Text
http://www.sciencedirect.com/science/article/pii/S0041134511017040
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