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Sirolimus-induced pneumonitis after renal transplantation: a single-center experience

DC FieldValueLanguage
dc.contributor.author김유선-
dc.contributor.author이형근-
dc.contributor.author주동진-
dc.contributor.author허규하-
dc.contributor.author김명수-
dc.contributor.author김순일-
dc.date.accessioned2014-12-19T17:44:02Z-
dc.date.available2014-12-19T17:44:02Z-
dc.date.issued2012-
dc.identifier.issn0041-1345-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/91953-
dc.description.abstractPURPOSE: Sirolimus is a potent immunosuppressive agent used with increasing frequency in kidney transplantation. However, sirolimus can increase the rate of unexplained interstitial pneumonitis. The aim of this study was to evaluate the clinical characteristics of sirolimus-induced pneumonitis and the therapeutic results in renal transplant recipients. PATIENTS AND METHODS: Seventy-two patients received sirolimus, conversion or de novo regimen, at our center between January 2007 and April 2011. Twelve of the 72 patients (16.7%) developed interstitial pneumonitis. The patients were divided into three groups according to the following indications of sirolimus use: de novo, early conversion, and late conversion groups. RESULTS: The mean duration of follow-up was 11.0 ± 11.5 months. The mean blood level of sirolimus measured by microparticulate enzyme immunoassay was 16.5 ± 7.4 ng/mL at the time of diagnosis. The mean time from the start of sirolimus to pneumonitis onset was 14.7 ± 8.0 months. The clinical presentation included fever, cough, dyspnea, general weakness, and periorbital edema. In most cases, radiological imaging tests revealed bilateral lower-lobe involvement. Bronchoalveolar lavage was performed in three patients and two patients showed lymphocytic alveolitis. Sirolimus was discontinued or reduced for the treatment of pneumonitis. All cases of pneumonitis were resolved within 2 to 4 weeks. CONCLUSION: Sirolimus blood level should be monitored tightly and early intervention is important when sirolimus-induced pneumonitis is suspected.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfTRANSPLANTATION PROCEEDINGS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAnalysis of Variance-
dc.subject.MESHDrug Monitoring-
dc.subject.MESHFemale-
dc.subject.MESHGraft Rejection/immunology-
dc.subject.MESHGraft Rejection/prevention & control-
dc.subject.MESHGraft Survival/drug effects-
dc.subject.MESHHumans-
dc.subject.MESHImmunosuppressive Agents/adverse effects*-
dc.subject.MESHImmunosuppressive Agents/blood-
dc.subject.MESHImmunosuppressive Agents/pharmacokinetics-
dc.subject.MESHKidney Transplantation*/immunology-
dc.subject.MESHLung Diseases, Interstitial/chemically induced*-
dc.subject.MESHLung Diseases, Interstitial/diagnosis-
dc.subject.MESHLung Diseases, Interstitial/therapy-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHRepublic of Korea-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHSirolimus/adverse effects*-
dc.subject.MESHSirolimus/blood-
dc.subject.MESHSirolimus/pharmacokinetics-
dc.subject.MESHTime Factors-
dc.subject.MESHTreatment Outcome-
dc.titleSirolimus-induced pneumonitis after renal transplantation: a single-center experience-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Ophthalmology (안과학)-
dc.contributor.googleauthorH.S. Lee-
dc.contributor.googleauthorK.H. Huh-
dc.contributor.googleauthorY.S. Kim-
dc.contributor.googleauthorM.S. Kim-
dc.contributor.googleauthorH.J. Kim-
dc.contributor.googleauthorS.I. Kim-
dc.contributor.googleauthorD.J. Joo-
dc.identifier.doi22310604-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00785-
dc.contributor.localIdA03303-
dc.contributor.localIdA03948-
dc.contributor.localIdA04344-
dc.contributor.localIdA00649-
dc.contributor.localIdA00424-
dc.relation.journalcodeJ02755-
dc.identifier.eissn1873-2623-
dc.identifier.pmid22310604-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S0041134511016563-
dc.subject.keywordAdult-
dc.subject.keywordAnalysis of Variance-
dc.subject.keywordDrug Monitoring-
dc.subject.keywordFemale-
dc.subject.keywordGraft Rejection/immunology-
dc.subject.keywordGraft Rejection/prevention & control-
dc.subject.keywordGraft Survival/drug effects-
dc.subject.keywordHumans-
dc.subject.keywordImmunosuppressive Agents/adverse effects*-
dc.subject.keywordImmunosuppressive Agents/blood-
dc.subject.keywordImmunosuppressive Agents/pharmacokinetics-
dc.subject.keywordKidney Transplantation*/immunology-
dc.subject.keywordLung Diseases, Interstitial/chemically induced*-
dc.subject.keywordLung Diseases, Interstitial/diagnosis-
dc.subject.keywordLung Diseases, Interstitial/therapy-
dc.subject.keywordMale-
dc.subject.keywordMiddle Aged-
dc.subject.keywordRepublic of Korea-
dc.subject.keywordRetrospective Studies-
dc.subject.keywordSirolimus/adverse effects*-
dc.subject.keywordSirolimus/blood-
dc.subject.keywordSirolimus/pharmacokinetics-
dc.subject.keywordTime Factors-
dc.subject.keywordTreatment Outcome-
dc.contributor.alternativeNameKim, Yu Seun-
dc.contributor.alternativeNameLee, Hyung Keun-
dc.contributor.alternativeNameJoo, Dong Jin-
dc.contributor.alternativeNameHuh, Kyu Ha-
dc.contributor.alternativeNameKim, Myoung Soo-
dc.contributor.alternativeNameKim, Soon Il-
dc.contributor.affiliatedAuthorKim, Yu Seun-
dc.contributor.affiliatedAuthorLee, Hyung Keun-
dc.contributor.affiliatedAuthorJoo, Dong Jin-
dc.contributor.affiliatedAuthorHuh, Kyu Ha-
dc.contributor.affiliatedAuthorKim, Soon Il-
dc.contributor.affiliatedAuthorKim, Myoung Soo-
dc.citation.volume44-
dc.citation.number1-
dc.citation.startPage161-
dc.citation.endPage163-
dc.identifier.bibliographicCitationTRANSPLANTATION PROCEEDINGS, Vol.44(1) : 161-163, 2012-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers

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