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Analysis of transplant outcomes after five or six human leukocyte antigen-mismatched living donor kidney transplantation

DC FieldValueLanguage
dc.contributor.author김명수-
dc.contributor.author김순일-
dc.contributor.author김유선-
dc.contributor.author이형근-
dc.contributor.author주동진-
dc.contributor.author주만기-
dc.contributor.author허규하-
dc.date.accessioned2014-12-19T17:43:58Z-
dc.date.available2014-12-19T17:43:58Z-
dc.date.issued2012-
dc.identifier.issn0041-1345-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/91951-
dc.description.abstractBACKGROUND: Recently, the impact of human leukocyte antigen (HLA) mismatch (MM) on graft outcome has diminished since the introduction of potent immunosuppressive agents, whereas previous reports support the notion that greater numbers of HLA matches are beneficial. This study was undertaken to evaluate outcomes after five or six HLA-mismatched living donor kidney transplantations (LDKT). METHODS: The authors retrospectively reviewed graft function after 2687 LDKTs performed between June 1984 and February 2010. A database of 1364 living related and 1063 living-unrelated donor (LURD) kidney transplantations was used for this study. LURD kidney transplantations were classified into three groups; (1) zero to one HLA MM (n = 158); (2) two to four HLA MM (n = 851); and (3) five to six MM (n = 54). An acute rejection episode was diagnosed based on clinical deterioration of graft function or biopsy findings. Graft survival was calculated using the Kaplan-Meier method. RESULTS: Graft survivals in the zero to one HLA MM, two to four HLA MM, five to six HLA MM, and one-haplo MM LDKT were not significantly different. The rates of acute rejection episodes within 1 year after transplantation were similar irrespective of the HLA MM; (1) zero to one HLA MM (37.3%), (2) two to four HLA MM (35.3%), (3) five to six HLA MM (33.3%; P = .832). CONCLUSIONS: Survival of five or six HLA-mismatched LDKTs was comparable to that of one-haplo MM and relatively well-matched LDKT. The study showed that the presence of five or six HLA MM was not a risk factor for graft survival after LDKT.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfTRANSPLANTATION PROCEEDINGS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAnalysis of Variance-
dc.subject.MESHBiopsy-
dc.subject.MESHChi-Square Distribution-
dc.subject.MESHFemale-
dc.subject.MESHGraft Rejection/immunology-
dc.subject.MESHGraft Rejection/prevention & control-
dc.subject.MESHGraft Survival/drug effects-
dc.subject.MESHHLA Antigens/immunology*-
dc.subject.MESHHistocompatibility*-
dc.subject.MESHHistocompatibility Testing-
dc.subject.MESHHumans-
dc.subject.MESHImmunosuppressive Agents/therapeutic use-
dc.subject.MESHIsoantibodies/blood*-
dc.subject.MESHKaplan-Meier Estimate-
dc.subject.MESHKidney Transplantation/immunology*-
dc.subject.MESHLiving Donors/supply & distribution*-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHRepublic of Korea-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHRisk Assessment-
dc.subject.MESHRisk Factors-
dc.subject.MESHTime Factors-
dc.subject.MESHTreatment Outcome-
dc.subject.MESHUnrelated Donors/supply & distribution*-
dc.titleAnalysis of transplant outcomes after five or six human leukocyte antigen-mismatched living donor kidney transplantation-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Ophthalmology (안과학)-
dc.contributor.googleauthorH.S. Lee-
dc.contributor.googleauthorM.S. Kim-
dc.contributor.googleauthorY.S. Kim-
dc.contributor.googleauthorD.J. Joo-
dc.contributor.googleauthorM.K. Ju-
dc.contributor.googleauthorS.J. Kim-
dc.contributor.googleauthorS.I. Kim-
dc.contributor.googleauthorK.H. Huh-
dc.contributor.googleauthorK. Park-
dc.identifier.doi22310631-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00649-
dc.contributor.localIdA00785-
dc.contributor.localIdA03303-
dc.contributor.localIdA03948-
dc.contributor.localIdA03949-
dc.contributor.localIdA04344-
dc.contributor.localIdA00424-
dc.relation.journalcodeJ02755-
dc.identifier.eissn1873-2623-
dc.identifier.pmid22310631-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S0041134511016551-
dc.subject.keywordAdult-
dc.subject.keywordAnalysis of Variance-
dc.subject.keywordBiopsy-
dc.subject.keywordChi-Square Distribution-
dc.subject.keywordFemale-
dc.subject.keywordGraft Rejection/immunology-
dc.subject.keywordGraft Rejection/prevention & control-
dc.subject.keywordGraft Survival/drug effects-
dc.subject.keywordHLA Antigens/immunology*-
dc.subject.keywordHistocompatibility*-
dc.subject.keywordHistocompatibility Testing-
dc.subject.keywordHumans-
dc.subject.keywordImmunosuppressive Agents/therapeutic use-
dc.subject.keywordIsoantibodies/blood*-
dc.subject.keywordKaplan-Meier Estimate-
dc.subject.keywordKidney Transplantation/immunology*-
dc.subject.keywordLiving Donors/supply & distribution*-
dc.subject.keywordMale-
dc.subject.keywordMiddle Aged-
dc.subject.keywordRepublic of Korea-
dc.subject.keywordRetrospective Studies-
dc.subject.keywordRisk Assessment-
dc.subject.keywordRisk Factors-
dc.subject.keywordTime Factors-
dc.subject.keywordTreatment Outcome-
dc.subject.keywordUnrelated Donors/supply & distribution*-
dc.contributor.alternativeNameKim, Myoung Soo-
dc.contributor.alternativeNameKim, Soon Il-
dc.contributor.alternativeNameKim, Yu Seun-
dc.contributor.alternativeNameLee, Hyung Keun-
dc.contributor.alternativeNameJoo, Dong Jin-
dc.contributor.alternativeNameJoo, Man Ki-
dc.contributor.alternativeNameHuh, Kyu Ha-
dc.contributor.affiliatedAuthorKim, Soon Il-
dc.contributor.affiliatedAuthorKim, Yu Seun-
dc.contributor.affiliatedAuthorLee, Hyung Keun-
dc.contributor.affiliatedAuthorJoo, Dong Jin-
dc.contributor.affiliatedAuthorJoo, Man Ki-
dc.contributor.affiliatedAuthorHuh, Kyu Ha-
dc.contributor.affiliatedAuthorKim, Myoung Soo-
dc.citation.volume44-
dc.citation.number1-
dc.citation.startPage273-
dc.citation.endPage275-
dc.identifier.bibliographicCitationTRANSPLANTATION PROCEEDINGS, Vol.44(1) : 273-275, 2012-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers

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