Cited 54 times in
Particulate air pollution induces arrhythmia via oxidative stress and calcium calmodulin kinase II activation
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 박희남 | - |
dc.contributor.author | 신동천 | - |
dc.contributor.author | 이문형 | - |
dc.contributor.author | 정보영 | - |
dc.contributor.author | 최은미 | - |
dc.contributor.author | 황기철 | - |
dc.contributor.author | 김창수 | - |
dc.contributor.author | 박혜림 | - |
dc.date.accessioned | 2014-12-19T17:43:44Z | - |
dc.date.available | 2014-12-19T17:43:44Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 0041-008X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/91944 | - |
dc.description.abstract | Ambient particulate matter (PM) can increase the incidence of arrhythmia. However, the arrhythmogenic mechanism of PM is poorly understood. This study investigated the arrhythmogenic mechanism of PM. In Sprague-Dawley rats, QT interval was increased from 115.0±14.0 to 142.1±18.4ms (p=0.02) after endotracheal exposure of DEP (200μg/ml for 30min, n=5). Ventricular premature contractions were more frequently observed after DEP exposure (100%) than baseline (20%, p=0.04). These effects were prevented by pretreatment of N-acetylcysteine (NAC, 5mmol/L, n=3). In 12 Langendorff-perfused rat hearts, DEP infusion of 12.5μg/ml for 20min prolonged action potential duration (APD) at only left ventricular base increasing apicobasal repolarization gradients. Spontaneous early afterdepolarization (EAD) and ventricular tachycardia (VT) were observed in 8 (67%) and 6 (50%) hearts, respectively, versus no spontaneous triggered activity or VT in any hearts before DEP infusion. DEP-induced APD prolongation, EAD and VT were successfully prevented with NAC (5mmol/L, n=5), nifedipine (10μmol/L, n=5), and active Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) blockade, KN 93 (1μmol/L, n=5), but not by thapsigargin (200nmol/L) plus ryanodine (10μmol/L, n=5) and inactive CaMKII blockade, KN 92 (1μmol/L, n=5). In neonatal rat cardiomyocytes, DEP provoked ROS generation in dose dependant manner. DEP (12.5μg/ml) induced apoptosis, and this effect was prevented by NAC and KN 93. Thus, this study shows that in vivo and vitro exposure of PM induced APD prolongation, EAD and ventricular arrhythmia. These effects might be caused by oxidative stress and CaMKII activation. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | TOXICOLOGY AND APPLIED PHARMACOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Acetylcysteine/pharmacology | - |
dc.subject.MESH | Action Potentials/drug effects | - |
dc.subject.MESH | Air Pollutants/toxicity* | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Animals, Newborn | - |
dc.subject.MESH | Apoptosis/drug effects | - |
dc.subject.MESH | Arrhythmias, Cardiac/chemically induced* | - |
dc.subject.MESH | Arrhythmias, Cardiac/enzymology | - |
dc.subject.MESH | Arrhythmias, Cardiac/metabolism | - |
dc.subject.MESH | Arrhythmias, Cardiac/prevention & control | - |
dc.subject.MESH | Calcium-Calmodulin-Dependent Protein Kinase Type 2/metabolism* | - |
dc.subject.MESH | Cells, Cultured | - |
dc.subject.MESH | Dose-Response Relationship, Drug | - |
dc.subject.MESH | Enzyme Activation | - |
dc.subject.MESH | Immunoblotting | - |
dc.subject.MESH | Immunohistochemistry | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Myocytes, Cardiac/drug effects | - |
dc.subject.MESH | Myocytes, Cardiac/metabolism | - |
dc.subject.MESH | Oxidative Stress/drug effects* | - |
dc.subject.MESH | Particulate Matter/toxicity* | - |
dc.subject.MESH | Rats | - |
dc.subject.MESH | Rats, Sprague-Dawley | - |
dc.subject.MESH | Reactive Oxygen Species/metabolism | - |
dc.subject.MESH | Vehicle Emissions/toxicity* | - |
dc.subject.MESH | Ventricular Premature Complexes/chemically induced | - |
dc.subject.MESH | Ventricular Premature Complexes/enzymology | - |
dc.subject.MESH | Ventricular Premature Complexes/metabolism | - |
dc.subject.MESH | Ventricular Premature Complexes/prevention & control | - |
dc.subject.MESH | Voltage-Sensitive Dye Imaging | - |
dc.title | Particulate air pollution induces arrhythmia via oxidative stress and calcium calmodulin kinase II activation | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Life Science (의생명과학부) | - |
dc.contributor.googleauthor | Jin-Bae Kim | - |
dc.contributor.googleauthor | Changsoo Kim | - |
dc.contributor.googleauthor | Eunmi Choi | - |
dc.contributor.googleauthor | Sanghoon Park | - |
dc.contributor.googleauthor | Hyelim Park | - |
dc.contributor.googleauthor | Hui-Nam Pak | - |
dc.contributor.googleauthor | Moon-Hyoung Lee | - |
dc.contributor.googleauthor | Dong Chun Shin | - |
dc.contributor.googleauthor | Ki-Chul Hwang | - |
dc.contributor.googleauthor | Boyoung Joung | - |
dc.identifier.doi | 10.1016/j.taap.2011.12.007 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01776 | - |
dc.contributor.localId | A02096 | - |
dc.contributor.localId | A02766 | - |
dc.contributor.localId | A03609 | - |
dc.contributor.localId | A04456 | - |
dc.contributor.localId | A01042 | - |
dc.contributor.localId | A01760 | - |
dc.contributor.localId | A04151 | - |
dc.relation.journalcode | J02742 | - |
dc.identifier.eissn | 1096-0333 | - |
dc.identifier.pmid | 22197715 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0041008X11004649 | - |
dc.subject.keyword | Particulate matter | - |
dc.subject.keyword | Oxidative stress | - |
dc.subject.keyword | Ca2 +/calmodulin-dependent protein kinase II | - |
dc.subject.keyword | Ventricular tachycardia | - |
dc.subject.keyword | Ventricular fibrillation | - |
dc.contributor.alternativeName | Pak, Hui Nam | - |
dc.contributor.alternativeName | Shin, Dong Chun | - |
dc.contributor.alternativeName | Lee, Moon Hyoung | - |
dc.contributor.alternativeName | Joung, Bo Young | - |
dc.contributor.alternativeName | Choi, Eun Mi | - |
dc.contributor.alternativeName | Hwang, Ki Chul | - |
dc.contributor.alternativeName | Kim, Chang Soo | - |
dc.contributor.alternativeName | Park, Hye Lim | - |
dc.contributor.affiliatedAuthor | Pak, Hui Nam | - |
dc.contributor.affiliatedAuthor | Shin, Dong Chun | - |
dc.contributor.affiliatedAuthor | Lee, Moon Hyoung | - |
dc.contributor.affiliatedAuthor | Joung, Bo Young | - |
dc.contributor.affiliatedAuthor | Hwang, Ki Chul | - |
dc.contributor.affiliatedAuthor | Kim, Chang Soo | - |
dc.contributor.affiliatedAuthor | Park, Hye Lim | - |
dc.contributor.affiliatedAuthor | Choi, Eun Mi | - |
dc.citation.volume | 259 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 66 | - |
dc.citation.endPage | 73 | - |
dc.identifier.bibliographicCitation | TOXICOLOGY AND APPLIED PHARMACOLOGY, Vol.259(1) : 66-73, 2012 | - |
dc.identifier.rimsid | 30020 | - |
dc.type.rims | ART | - |
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