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Curved biodegradable microneedles for vascular drug delivery

Authors
 Chang Kuk Choi ; Jin Bum Kim ; Won Hyoung Ryu ; Young-Nam Youn ; Eui Hwa Jang 
Citation
 Small, Vol.8(16) : 2483~2488, 2012 
Journal Title
 Small 
ISSN
 1613-6810 
Issue Date
2012
Abstract
Curved biodegradable microneedles for application to the outer surface of blood vessels are produced to enhance drug delivery to vascular tissues suffering from hyperplasia or atherosclerosis. Spatially discrete thermal drawing and post-annealing processes are employed to fabricate microneedles on a curved surface. Insertion of microneedles into arteries in vivo and ex vivo is demonstrated, and their mechanical properties and drug-delivery function are studied
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/91856
DOI
10.1002/smll.201200441
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Thoracic & Cardiovascular Surgery
Yonsei Authors
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Link
 http://onlinelibrary.wiley.com/doi/10.1002/smll.201200441/abstract
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