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Curved biodegradable microneedles for vascular drug delivery

Authors
 Chang Kuk Choi  ;  Jin Bum Kim  ;  Eui Hwa Jang  ;  Young-Nam Youn  ;  Won Hyoung Ryu 
Citation
 SMALL, Vol.8(16) : 2483-2488, 2012 
Journal Title
 SMALL 
ISSN
 1613-6810 
Issue Date
2012
MeSH
Animals ; Biocompatible Materials/chemistry* ; Biodegradation, Environmental ; Blood Vessels/physiology* ; Dogs ; Drug Delivery Systems/instrumentation* ; Microinjections/instrumentation* ; Microscopy, Electron, Scanning ; Microscopy, Fluorescence ; Needles* ; Rabbits
Keywords
Animals ; Biocompatible Materials/chemistry* ; Biodegradation, Environmental ; Blood Vessels/physiology* ; Dogs ; Drug Delivery Systems/instrumentation* ; Microinjections/instrumentation* ; Microscopy, Electron, Scanning ; Microscopy, Fluorescence ; Needles* ; Rabbits
Abstract
Curved biodegradable microneedles for application to the outer surface of blood vessels are produced to enhance drug delivery to vascular tissues suffering from hyperplasia or atherosclerosis. Spatially discrete thermal drawing and post-annealing processes are employed to fabricate microneedles on a curved surface. Insertion of microneedles into arteries in vivo and ex vivo is demonstrated, and their mechanical properties and drug-delivery function are studied
Full Text
http://onlinelibrary.wiley.com/doi/10.1002/smll.201200441/abstract
DOI
22628194
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Thoracic and Cardiovascular Surgery (흉부외과학교실) > 1. Journal Papers
Yonsei Authors
Youn, Young Nam(윤영남)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/91856
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