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Nuclear localization of folate receptor alpha: a new role as a transcription factor

Authors
 Vanda Boshnjaku  ;  Kyu-Won Shim  ;  Takao Tsurubuchi  ;  Shunsuke Ichi  ;  Elise V. Szany  ;  Guifa Xi  ;  Barbara Mania-Farnell  ;  David G. McLone  ;  Tadanori Tomita  ;  C. Shekhar Mayanil 
Citation
 SCIENTIFIC REPORTS, Vol.2 : 980, 2012 
Journal Title
 SCIENTIFIC REPORTS 
Issue Date
2012
MeSH
Animals ; Basic Helix-Loop-Helix Transcription Factors/genetics ; Basic Helix-Loop-Helix Transcription Factors/metabolism ; Cell Line, Tumor ; Cell Nucleus/drug effects ; Cell Nucleus/metabolism* ; Consensus Sequence ; Folate Receptor 1/metabolism* ; Folic Acid/pharmacology ; Humans ; Mice ; Promoter Regions, Genetic ; Protein Binding ; Receptor, Fibroblast Growth Factor, Type 4/genetics ; Receptor, Fibroblast Growth Factor, Type 4/metabolism ; Regulatory Elements, Transcriptional ; Transfection
Keywords
Animals ; Basic Helix-Loop-Helix Transcription Factors/genetics ; Basic Helix-Loop-Helix Transcription Factors/metabolism ; Cell Line, Tumor ; Cell Nucleus/drug effects ; Cell Nucleus/metabolism* ; Consensus Sequence ; Folate Receptor 1/metabolism* ; Folic Acid/pharmacology ; Humans ; Mice ; Promoter Regions, Genetic ; Protein Binding ; Receptor, Fibroblast Growth Factor, Type 4/genetics ; Receptor, Fibroblast Growth Factor, Type 4/metabolism ; Regulatory Elements, Transcriptional ; Transfection
Abstract
Folic acid (FA) has traditionally been associated with prevention of neural tube defects; more recent work suggests that it may also be involved in in the prevention of adult onset diseases. As the role of FA in human health and disease expands, it also becomes more critical to understand the mechanisms behind FA action. In this work we examined the hypothesis that folate receptor alpha (FRα) acts as a transcription factor. FRα is a GPI-anchored protein and a component of the caveolae fraction. The work described here shows that FRα translocates to the nucleus, where it binds to cis-regulatory elements at promoter regions of Fgfr4 and Hes1, and regulates their expression. The FRα recognition domain mapped to AT rich regions on the promoters. Until this time FRα has only been considered as a folate transporter, these studies describe a novel role for FRα as a transcription factor.
Files in This Item:
T201205489.pdf Download
DOI
23243496
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
Yonsei Authors
Shim, Kyu Won(심규원) ORCID logo https://orcid.org/0000-0002-9441-7354
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/91841
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