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Nuclear localization of folate receptor alpha: a new role as a transcription factor

Authors
 Vanda Boshnjaku  ;  Kyu-Won Shim  ;  Takao Tsurubuchi  ;  Shunsuke Ichi  ;  Elise V. Szany  ;  Guifa Xi  ;  Barbara Mania-Farnell  ;  David G. McLone  ;  Tadanori Tomita  ;  C. Shekhar Mayanil 
Citation
 Scientific Reports, Vol.2 : 980-980, 2012 
Journal Title
 Scientific Reports 
ISSN
 2045-2322 
Issue Date
2012
Abstract
Folic acid (FA) has traditionally been associated with prevention of neural tube defects; more recent work suggests that it may also be involved in in the prevention of adult onset diseases. As the role of FA in human health and disease expands, it also becomes more critical to understand the mechanisms behind FA action. In this work we examined the hypothesis that folate receptor alpha (FRα) acts as a transcription factor. FRα is a GPI-anchored protein and a component of the caveolae fraction. The work described here shows that FRα translocates to the nucleus, where it binds to cis-regulatory elements at promoter regions of Fgfr4 and Hes1, and regulates their expression. The FRα recognition domain mapped to AT rich regions on the promoters. Until this time FRα has only been considered as a folate transporter, these studies describe a novel role for FRα as a transcription factor.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/91841
DOI
10.1038/srep00980
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실)
Yonsei Authors
심규원(Shim, Kyu Won)
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