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Changing epidemiology of nontuberculous mycobacterial lung disease in South Korea

Authors
 Sang Kook Lee  ;  Eun Ja Lee  ;  Se Kyu Kim  ;  Joon Chang  ;  Seok Hoon Jeong  ;  Young Ae Kang 
Citation
 Scandinavian Journal of Infectious Diseases, Vol.44(10) : 733-738, 2012 
Journal Title
 Scandinavian Journal of Infectious Diseases 
ISSN
 0036-5548 
Issue Date
2012
Abstract
OBJECTIVES: Pulmonary nontuberculous mycobacteria (NTM) are increasing worldwide, but data from regions with an intermediate tuberculosis (TB) burden are insufficient, and the reason for the changing epidemiology of NTM lung disease is unclear. We investigated the trends of NTM lung disease at a tertiary hospital in Korea and evaluated the contribution of liquid culture systems. METHODS: We conducted a retrospective observational study of mycobacterial cultures of respiratory specimens from 26,793 patients at Severance Hospital in South Korea from January 2006 to December 2010. RESULTS: The recovery percent of Mycobacterium tuberculosis isolates was 5.9% in 2006 and 7.1% in 2010, and the recovery percent of NTM isolates was 2.0% in 2006 and 6.3% in 2010. The annual percent of NTM isolation has increased steadily every year (p for trend < 0.001), and the proportion of patients from whom NTM was isolated increased from 21.4% in 2006 to 55.0% in 2010 (p for trend < 0.001). The incidence (per 100,000 inpatients and outpatients) of patients with NTM lung disease was 1.82 in 2006 and increased to 4.38 in 2010 (p < 0.001). Although the proportion of positive cultures in liquid medium only was higher for NTM than for M. tuberculosis (p < 0.001), the NTM recovery rate has increased in solid medium culture systems. CONCLUSIONS: The incidence of patients with NTM isolated from respiratory specimens and NTM lung disease increased from 2006 to 2010 in South Korea, a region with an intermediate TB burden
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/91830
DOI
10.3109/00365548.2012.681695
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실)
Yonsei Authors
강영애(Kang, Young Ae)
김세규(Kim, Se Kyu)
이상국(Lee, Sang Kook)
장준(Chang, Joon)
정석훈(Jeong, Seok Hoon)
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Full Text
http://informahealthcare.com/doi/abs/10.3109/00365548.2012.681695
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