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Tuberculin reaction is not attenuated in patients with rheumatoid arthritis living in a region with intermediate burden of tuberculosis

 Kwang-Hoon Lee  ;  Sang-Youn Jung  ;  You-Jung Ha  ;  Soo-Kon Lee  ;  Yong-Beom Park 
 RHEUMATOLOGY INTERNATIONAL, Vol.32(5) : 1421-1424, 2012 
Journal Title
Issue Date
Adult ; Antirheumatic Agents/adverse effects ; Antirheumatic Agents/therapeutic use* ; Arthritis, Rheumatoid/diagnosis ; Arthritis, Rheumatoid/drug therapy* ; Arthritis, Rheumatoid/epidemiology ; Arthritis, Rheumatoid/immunology ; Case-Control Studies ; Chi-Square Distribution ; Female ; Humans ; Latent Tuberculosis/diagnosis* ; Latent Tuberculosis/epidemiology ; Latent Tuberculosis/immunology ; Logistic Models ; Male ; Middle Aged ; Multivariate Analysis ; Predictive Value of Tests ; Republic of Korea/epidemiology ; Risk Assessment ; Risk Factors ; Severity of Illness Index ; Tuberculin Test* ; Tumor Necrosis Factor-alpha/antagonists & inhibitors
Rheumatoid arthritis ; Latent tuberculosis infection ; Tuberculin skin test ; Anti-TNF-α agent
Tuberculin reactions in patients with immunocompromised conditions have been reported to be attenuated compared with healthy controls. In the case of rheumatoid arthritis (RA), several studies have reported conflicting results. We performed this study to evaluate the tuberculin reaction in patients with RA in a region with intermediate burden of tuberculosis. Eighty-one RA patients and 104 age- and sex-matched controls who underwent tuberculin skin test (TST) at Severance Hospital in Seoul, South Korea were reviewed. TST was carried out using the Mantoux method. Indurations larger than 10 mm were considered positive. Information about risk factors for latent tuberculosis infection was acquired. The mean age of the patients with RA was 48 ± 14 years, and the median disease duration was 9 (1-203) months. The mean DAS28 was 5.22 ± 0.13. The control group consisted of healthy living donors for liver transplantation and the patients with diseases not related with immunosuppression. BCG vaccination, close contact history with active tuberculosis, and history of pulmonary tuberculosis were not different between the two groups. The positive rate of TST (34.6% vs. 38.5%) and the median skin induration size (5 mm vs. 6 mm) of the two groups were similar. Medications and DAS28 were not associated with the TST result. The tuberculin reaction of patients with RA is not attenuated compared with that of controls in South Korea.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Park, Yong Beom(박용범)
Lee, Kwang Hoon(이광훈)
Lee, Soo Kon(이수곤)
Ha, You Jung(하유정)
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