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Prognostic factors for visual outcome after intravitreal anti-VEGF injection for naive myopic choroidal neovascularization

DC Field Value Language
dc.contributor.author고형준-
dc.contributor.author김용민-
dc.contributor.author변여주-
dc.date.accessioned2014-12-19T17:38:59Z-
dc.date.available2014-12-19T17:38:59Z-
dc.date.issued2012-
dc.identifier.issn0275-004X-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/91809-
dc.description.abstractPURPOSE: The aim of this study was to evaluate the prognostic factors of visual outcome after intravitreal anti-vascular endothelial growth factor injection in patients with myopic choroidal neovascularization (CNV). METHODS: Forty eyes of 40 consecutive patients with myopic CNV who had received intravitreal ranibizumab or bevacizumab injections were retrospectively reviewed. Baseline visual acuity, presence of lacquer crack, dark rim, peripapillary choroidal atrophy size, and location of myopic CNV were evaluated using fluorescein angiography and indocyanine green angiography. RESULTS: The logarithm of the minimum angle of resolution best-corrected visual acuity (BCVA) at 12 months after treatment was 0.23 ± 0.28, and there was a significant improvement compared with the baseline BCVA (P = 0.001). After multiple linear regression analysis, baseline BCVA, presence of lacquer crack extending the fovea, and peripapillary choroidal atrophy size were the factors that significantly correlated with BCVA at 12 months (P = 0.001, P = 0.04, and P = 0.04). For mean change in BCVA over 12 months, there were also significant correlations with baseline BCVA, lacquer crack extension to the fovea, and peripapillary choroidal atrophy size (P = 0.001, P = 0.03, and P = 0.03). The mean number of anti-vascular endothelial growth factor injections was 2.8 ± 2.0 over 12 months. Complete resolution of myopic CNV was noted in 22 eyes (55.0%) after initial first injection, and no additional treatment was required in 12 eyes (30%). CONCLUSION: Better baseline BCVA, lacquer crack extension to the fovea, and peripapillary atrophy were negative prognostic factors of visual acuity improvement, and there was quite a promising result of anti-vascular endothelial growth factor treatment in patients with myopic CNV.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfRETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAngiogenesis Inhibitors/administration & dosage*-
dc.subject.MESHAntibodies, Monoclonal, Humanized/administration & dosage-
dc.subject.MESHBevacizumab-
dc.subject.MESHChoroidal Neovascularization/diagnosis-
dc.subject.MESHChoroidal Neovascularization/drug therapy*-
dc.subject.MESHChoroidal Neovascularization/physiopathology-
dc.subject.MESHColoring Agents-
dc.subject.MESHFemale-
dc.subject.MESHFluorescein Angiography-
dc.subject.MESHHumans-
dc.subject.MESHIndocyanine Green-
dc.subject.MESHIntravitreal Injections-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHMyopia/diagnosis-
dc.subject.MESHMyopia/drug therapy*-
dc.subject.MESHMyopia/physiopathology-
dc.subject.MESHPrognosis-
dc.subject.MESHRanibizumab-
dc.subject.MESHRetreatment-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHTomography, Optical Coherence-
dc.subject.MESHTreatment Outcome-
dc.subject.MESHVascular Endothelial Growth Factor A/antagonists & inhibitors*-
dc.subject.MESHVisual Acuity/physiology*-
dc.titlePrognostic factors for visual outcome after intravitreal anti-VEGF injection for naive myopic choroidal neovascularization-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Ophthalmology (안과학)-
dc.contributor.googleauthorYoon, Jong UK-
dc.contributor.googleauthorKim, Yong Min-
dc.contributor.googleauthorLee, Sung Jun-
dc.contributor.googleauthorByun, Yeo Jue-
dc.contributor.googleauthorKoh, Hyoung Jun-
dc.identifier.doi22534553-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00152-
dc.contributor.localIdA00742-
dc.contributor.localIdA01851-
dc.relation.journalcodeJ02621-
dc.identifier.eissn1539-2864-
dc.identifier.pmid22534553-
dc.identifier.urlhttp://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00006982-201205000-00012&LSLINK=80&D=ovft-
dc.subject.keywordintravitreal anti-VEGF injection-
dc.subject.keywordmyopic choroidal neovascularization-
dc.contributor.alternativeNameKoh, Hyoung Jun-
dc.contributor.alternativeNameKim, Yong Min-
dc.contributor.alternativeNameByun, Yeo Jue-
dc.contributor.affiliatedAuthorKoh, Hyoung Jun-
dc.contributor.affiliatedAuthorKim, Yong Min-
dc.contributor.affiliatedAuthorByun, Yeo Jue-
dc.citation.volume32-
dc.citation.number5-
dc.citation.startPage949-
dc.citation.endPage955-
dc.identifier.bibliographicCitationRETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES, Vol.32(5) : 949-955, 2012-
dc.identifier.rimsid31210-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers

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