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Effects of high and low stress on proinflammatory and antiinflammatory cytokines

Authors
 Kyung Bong Koh  ;  Young-Joon Lee  ;  Keyng Min Beyn  ;  Sang Hee Chu  ;  Duck Man Kim  ;  Won Youl Seo 
Citation
 PSYCHOPHYSIOLOGY, Vol.49(9) : 1290-1297, 2012 
Journal Title
 PSYCHOPHYSIOLOGY 
ISSN
 0048-5772 
Issue Date
2012
MeSH
Adult ; Female ; Humans ; Interleukin-10/blood* ; Interleukin-6/blood* ; Male ; Psychometrics ; Stress, Psychological/blood* ; Stress, Psychological/psychology ; Students, Medical/psychology* ; Surveys and Questionnaires ; Tumor Necrosis Factor-alpha/blood*
Keywords
Adult ; Female ; Humans ; Interleukin-10/blood* ; Interleukin-6/blood* ; Male ; Psychometrics ; Stress, Psychological/blood* ; Stress, Psychological/psychology ; Students, Medical/psychology* ; Surveys and Questionnaires ; Tumor Necrosis Factor-alpha/blood*
Abstract
The effects of stress, which varies throughout an academic year, on proinflammatory and antiinflammatory cytokines were examined in 44 medical students. This was tested by comparing stimulated cytokines during a baseline period, stress period, and poststress vacation period. During the stress period, compared with the baseline period, levels of IL-6 were reduced, while levels of IL-10 were elevated. During the poststress vacation period, compared with the stress period, levels of IL-6 and TNF-α were increased. However, the changes in stress-related psychological and physiological variables were not significantly associated with changes in levels of proinflammatory and antiinflammatory cytokines. These results suggest that vacation is more likely to have a counterstress effect on proinflammatory cytokines than on an antiinflammatory cytokine and that a stressor may affect changes in immune function independently of self-reported stress.
Full Text
http://onlinelibrary.wiley.com/doi/10.1111/j.1469-8986.2012.01409.x/abstract
DOI
22803590
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Biomedical Systems Informatics (의생명시스템정보학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
Yonsei Authors
Koh, Kyung Bong(고경봉)
Seo, Won Youl(서원열)
Lee, Youngjoon(이영준) ORCID logo https://orcid.org/0000-0002-9602-5186
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/91772
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