Cited 0 times in
Alveolar macrophages play a key role in cockroach-induced allergic inflammation via TNF-α pathway
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 박중원 | - |
dc.contributor.author | 손정호 | - |
dc.contributor.author | 이재현 | - |
dc.contributor.author | 홍천수 | - |
dc.date.accessioned | 2014-12-19T17:36:15Z | - |
dc.date.available | 2014-12-19T17:36:15Z | - |
dc.date.issued | 2012 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/91721 | - |
dc.description.abstract | The activity of the serine protease in the German cockroach allergen is important to the development of allergic disease. The protease-activated receptor (PAR)-2, which is expressed in numerous cell types in lung tissue, is known to mediate the cellular events caused by inhaled serine protease. Alveolar macrophages express PAR-2 and produce considerable amounts of tumor necrosis factor (TNF)-α. We determined whether the serine protease in German cockroach extract (GCE) enhances TNF-α production by alveolar macrophages through the PAR-2 pathway and whether the TNF-α production affects GCE-induced pulmonary inflammation. Effects of GCE on alveolar macrophages and TNF-α production were evaluated using in vitro MH-S and RAW264.6 cells and in vivo GCE-induced asthma models of BALB/c mice. GCE contained a large amount of serine protease. In the MH-S and RAW264.7 cells, GCE activated PAR-2 and thereby produced TNF-α. In the GCE-induced asthma model, intranasal administration of GCE increased airway hyperresponsiveness (AHR), inflammatory cell infiltration, productions of serum immunoglobulin E, interleukin (IL)-5, IL-13 and TNF-α production in alveolar macrophages. Blockade of serine proteases prevented the development of GCE induced allergic pathologies. TNF-α blockade also prevented the development of such asthma-like lesions. Depletion of alveolar macrophages reduced AHR and intracellular TNF-α level in pulmonary cell populations in the GCE-induced asthma model. These results suggest that serine protease from GCE affects asthma through an alveolar macrophage and TNF-α dependent manner, reflecting the close relation of innate and adaptive immune response in allergic asthma model. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | e47971 | - |
dc.relation.isPartOf | PLOS ONE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adaptive Immunity/drug effects | - |
dc.subject.MESH | Administration, Intranasal | - |
dc.subject.MESH | Allergens/immunology* | - |
dc.subject.MESH | Allergens/pharmacology | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Asthma/chemically induced | - |
dc.subject.MESH | Asthma/immunology* | - |
dc.subject.MESH | Asthma/metabolism | - |
dc.subject.MESH | Asthma/pathology | - |
dc.subject.MESH | Blattellidae/chemistry* | - |
dc.subject.MESH | Blattellidae/enzymology | - |
dc.subject.MESH | Cell Line | - |
dc.subject.MESH | Complex Mixtures/chemistry | - |
dc.subject.MESH | Complex Mixtures/immunology* | - |
dc.subject.MESH | Complex Mixtures/pharmacology | - |
dc.subject.MESH | Gene Expression Regulation/drug effects | - |
dc.subject.MESH | Immunity, Innate/drug effects | - |
dc.subject.MESH | Immunoglobulin E/blood | - |
dc.subject.MESH | Inflammation/chemically induced | - |
dc.subject.MESH | Inflammation/immunology* | - |
dc.subject.MESH | Inflammation/metabolism | - |
dc.subject.MESH | Inflammation/pathology | - |
dc.subject.MESH | Insect Proteins/immunology* | - |
dc.subject.MESH | Insect Proteins/pharmacology | - |
dc.subject.MESH | Interleukin-13/blood | - |
dc.subject.MESH | Interleukin-5/blood | - |
dc.subject.MESH | Lung/immunology | - |
dc.subject.MESH | Lung/metabolism | - |
dc.subject.MESH | Lung/pathology | - |
dc.subject.MESH | Macrophages, Alveolar/immunology* | - |
dc.subject.MESH | Macrophages, Alveolar/metabolism | - |
dc.subject.MESH | Macrophages, Alveolar/pathology | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Mice, Inbred BALB C | - |
dc.subject.MESH | Receptor, PAR-2/genetics | - |
dc.subject.MESH | Receptor, PAR-2/immunology | - |
dc.subject.MESH | Serine Proteases/immunology* | - |
dc.subject.MESH | Serine Proteases/pharmacology | - |
dc.subject.MESH | Serine Proteinase Inhibitors/pharmacology | - |
dc.subject.MESH | Signal Transduction/drug effects | - |
dc.subject.MESH | Tumor Necrosis Factor-alpha/antagonists & inhibitors | - |
dc.subject.MESH | Tumor Necrosis Factor-alpha/immunology* | - |
dc.title | Alveolar macrophages play a key role in cockroach-induced allergic inflammation via TNF-α pathway | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Joo Young Kim | - |
dc.contributor.googleauthor | Jung Ho Sohn | - |
dc.contributor.googleauthor | Je-Min Choi | - |
dc.contributor.googleauthor | Jae-Hyun Lee | - |
dc.contributor.googleauthor | Chein-Soo Hong | - |
dc.contributor.googleauthor | Joo-Shil Lee | - |
dc.contributor.googleauthor | Jung-Won Park | - |
dc.identifier.doi | 23094102 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01681 | - |
dc.contributor.localId | A01993 | - |
dc.contributor.localId | A03086 | - |
dc.contributor.localId | A04448-1 | - |
dc.relation.journalcode | J02540 | - |
dc.identifier.eissn | 1932-6203 | - |
dc.identifier.pmid | 23094102 | - |
dc.subject.keyword | Adaptive Immunity/drug effects | - |
dc.subject.keyword | Administration, Intranasal | - |
dc.subject.keyword | Allergens/immunology* | - |
dc.subject.keyword | Allergens/pharmacology | - |
dc.subject.keyword | Animals | - |
dc.subject.keyword | Asthma/chemically induced | - |
dc.subject.keyword | Asthma/immunology* | - |
dc.subject.keyword | Asthma/metabolism | - |
dc.subject.keyword | Asthma/pathology | - |
dc.subject.keyword | Blattellidae/chemistry* | - |
dc.subject.keyword | Blattellidae/enzymology | - |
dc.subject.keyword | Cell Line | - |
dc.subject.keyword | Complex Mixtures/chemistry | - |
dc.subject.keyword | Complex Mixtures/immunology* | - |
dc.subject.keyword | Complex Mixtures/pharmacology | - |
dc.subject.keyword | Gene Expression Regulation/drug effects | - |
dc.subject.keyword | Immunity, Innate/drug effects | - |
dc.subject.keyword | Immunoglobulin E/blood | - |
dc.subject.keyword | Inflammation/chemically induced | - |
dc.subject.keyword | Inflammation/immunology* | - |
dc.subject.keyword | Inflammation/metabolism | - |
dc.subject.keyword | Inflammation/pathology | - |
dc.subject.keyword | Insect Proteins/immunology* | - |
dc.subject.keyword | Insect Proteins/pharmacology | - |
dc.subject.keyword | Interleukin-13/blood | - |
dc.subject.keyword | Interleukin-5/blood | - |
dc.subject.keyword | Lung/immunology | - |
dc.subject.keyword | Lung/metabolism | - |
dc.subject.keyword | Lung/pathology | - |
dc.subject.keyword | Macrophages, Alveolar/immunology* | - |
dc.subject.keyword | Macrophages, Alveolar/metabolism | - |
dc.subject.keyword | Macrophages, Alveolar/pathology | - |
dc.subject.keyword | Mice | - |
dc.subject.keyword | Mice, Inbred BALB C | - |
dc.subject.keyword | Receptor, PAR-2/genetics | - |
dc.subject.keyword | Receptor, PAR-2/immunology | - |
dc.subject.keyword | Serine Proteases/immunology* | - |
dc.subject.keyword | Serine Proteases/pharmacology | - |
dc.subject.keyword | Serine Proteinase Inhibitors/pharmacology | - |
dc.subject.keyword | Signal Transduction/drug effects | - |
dc.subject.keyword | Tumor Necrosis Factor-alpha/antagonists & inhibitors | - |
dc.subject.keyword | Tumor Necrosis Factor-alpha/immunology* | - |
dc.contributor.alternativeName | Park, Jung Won | - |
dc.contributor.alternativeName | Sohn, Jung Ho | - |
dc.contributor.alternativeName | Lee, Jae Hyun | - |
dc.contributor.alternativeName | Hong, Chein Soo | - |
dc.contributor.affiliatedAuthor | Park, Jung Won | - |
dc.contributor.affiliatedAuthor | Sohn, Jung Ho | - |
dc.contributor.affiliatedAuthor | Lee, Jae Hyun | - |
dc.contributor.affiliatedAuthor | Hong, Chein Soo | - |
dc.citation.volume | 7 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | e47971 | - |
dc.identifier.bibliographicCitation | PLOS ONE, Vol.7(10) : e47971, 2012 | - |
dc.identifier.rimsid | 29576 | - |
dc.type.rims | ART | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.