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Overexpression of class III beta tubulin and amplified HER2 gene predict good response to paclitaxel and trastuzumab therapy

Authors
 Minkyu Jung  ;  Ja Seung Koo  ;  Young Wha Moon  ;  Byeong-Woo Park  ;  Seung Il Kim  ;  Seho Park  ;  Soo Hyun Lee  ;  Soojung Hong  ;  Sun Young Rha  ;  Hyun Cheol Chung  ;  Joo Hang Kim  ;  Joohyuk Sohn 
Citation
 PLoS One, Vol.7(9) : e45127, 2012 
Journal Title
 PLoS One 
ISSN
 1932-6203 
Issue Date
2012
Abstract
Through this study, we aimed to validate several biomarkers that have been known to possibly predict the outcomes of the trastuzumab and paclitaxel (TP). Human epidermal growth factor 2 (HER2) positive metastatic breast cancer (MBC) patients who had been treated with TP in single institute from 2006 to 2009 were included in this study. For procured formalin fixed paraffin embedded tumor tissues, HER2 amplification index (AI) and polymorphisms of the immunoglobulin G fragment C receptors (FCGR) were assessed as biomarkers to the trastuzumab and expression of class III beta tubulin (bTubIII) was evaluated as a predictive factor to the paclitaxel. Of 46 patients treated with TP, 27 patients could be evaluated for HER2 AI, 31 for bTubIII, and 26 for FCGR gene polymorphism. The median of the HER2 AI was 5.0 (range, 1.4-15.5) and a higher HER2 AI (≥ 5.0) was significantly correlated with better response rate (RR) (80% vs. 42%, P=0.049) and longer progression-free survival (PFS) (13.6 vs. 6.9 months, P=0.023). High bTubIII expression showed higher RRs than did low expression (81% vs. 40%, P=0.040) in addition to longer PFS (16.2 months vs. 8.8 months, P=0.04). However, polymorphisms in FCGR 2A-H131R or FCGR 3A-V158F were not predictive of RR or PFS. Our results suggest that a high HER2 AI and high bTubIII expression could be predictive of the outcomes to TP therapy but no evidence was found in terms of FCGR polymorphisms.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/91715
Files in This Item:
T201203108.pdf Download
DOI
10.1371/journal.pone.0045127
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실)
Yonsei Authors
구자승(Koo, Ja Seung) ORCID logo https://orcid.org/0000-0003-4546-4709
김승일(Kim, Seung Il)
김주항(Kim, Joo Hang)
라선영(Rha, Sun Young)
문용화(Moon, Yong Wha)
박병우(Park, Byeong Woo)
박세호(Park, Se Ho)
손주혁(Sohn, Joo Hyuk)
이수현(Lee, Soo Hyeon)
정민규(Jung, Min Kyu) ORCID logo https://orcid.org/0000-0001-8281-3387
정현철(Chung, Hyun Cheol) ORCID logo https://orcid.org/0000-0002-0920-9471
홍수정(Hong, Soo Jung)
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