Cited 34 times in
The UGT1A3*2 polymorphism affects atorvastatin lactonization and lipid-lowering effect in healthy volunteers
DC Field | Value | Language |
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dc.contributor.author | 박경수 | - |
dc.contributor.author | 박민수 | - |
dc.contributor.author | 정재용 | - |
dc.contributor.author | 조성권 | - |
dc.date.accessioned | 2014-12-19T17:34:23Z | - |
dc.date.available | 2014-12-19T17:34:23Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 1744-6872 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/91662 | - |
dc.description.abstract | OBJECTIVE: We investigated whether the UGT1A3 polymorphisms play an important role in interindividual variations in atorvastatin lactonization and lipid-lowering effect. METHODS: Twenty-three healthy volunteers were administered atorvastatin 20 mg once daily for 14 days. Serum levels of lipids were measured before and 7, 13, 14, 15, 21, and 28 days after the initial dosing. Blood samples for pharmacokinetic analysis were collected up to 48 h after the last dose. RESULTS: The UGT1A3*2 and UGT1A1*28 polymorphism had a perfect linkage in the participants. Lactone formation was significantly higher in the UGT1A3*2 carriers. The areas under the curve of atorvastatin lactone and 2-hydroxyatorvastatin lactone were 72 and 160% higher in individuals with UGT1A3*2/*2 than UGT1A3*1/*1, respectively. The maximum percent decreases in the total and the low-density lipoprotein cholesterol from baseline in UGT1A3*2 carriers were 29 and 18% less than the UGT1A3*2 noncarriers, respectively. CONCLUSION: The UGT1A3*2 polymorphism is correlated with increased atorvastatin lactonization and may affect its lipid-lowering effect. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | PHARMACOGENETICS AND GENOMICS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | ATP Binding Cassette Transporter, Sub-Family G, Member 2 | - |
dc.subject.MESH | ATP-Binding Cassette Transporters/genetics | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Area Under Curve | - |
dc.subject.MESH | Atorvastatin Calcium | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Genotype | - |
dc.subject.MESH | Glucuronosyltransferase*/genetics | - |
dc.subject.MESH | Glucuronosyltransferase*/metabolism | - |
dc.subject.MESH | Heptanoic Acids/administration & dosage | - |
dc.subject.MESH | Heptanoic Acids/pharmacokinetics | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Lactones/metabolism | - |
dc.subject.MESH | Lipid Metabolism/genetics* | - |
dc.subject.MESH | Lipids/blood* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Neoplasm Proteins/genetics | - |
dc.subject.MESH | Polymorphism, Genetic* | - |
dc.subject.MESH | Pyrroles/administration & dosage | - |
dc.subject.MESH | Pyrroles/pharmacokinetics | - |
dc.title | The UGT1A3*2 polymorphism affects atorvastatin lactonization and lipid-lowering effect in healthy volunteers | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pharmacology (약리학) | - |
dc.contributor.googleauthor | Cho, Sung Kweon | - |
dc.contributor.googleauthor | Oh, Eun Sil | - |
dc.contributor.googleauthor | Park, Kyungsoo | - |
dc.contributor.googleauthor | Park, Min Soo | - |
dc.contributor.googleauthor | Chung, Jae Yong | - |
dc.identifier.doi | 10.1097/FPC.0b013e3283544085 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01422 | - |
dc.contributor.localId | A01468 | - |
dc.contributor.localId | A03709 | - |
dc.contributor.localId | A03829 | - |
dc.relation.journalcode | J02506 | - |
dc.identifier.eissn | 1744-6880 | - |
dc.identifier.pmid | 22555810 | - |
dc.identifier.url | http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=01213011-201208000-00004&LSLINK=80&D=ovft | - |
dc.subject.keyword | atorvastatin | - |
dc.subject.keyword | lipids | - |
dc.subject.keyword | pharmacogenetics | - |
dc.subject.keyword | pharmacokinetics | - |
dc.subject.keyword | UGT1A1 | - |
dc.subject.keyword | UGT1A3 | - |
dc.contributor.alternativeName | Park, Kyung Soo | - |
dc.contributor.alternativeName | Park, Min Soo | - |
dc.contributor.alternativeName | Chung, Jae Yong | - |
dc.contributor.alternativeName | Cho, Sung Kweon | - |
dc.contributor.affiliatedAuthor | Park, Kyung Soo | - |
dc.contributor.affiliatedAuthor | Park, Min Soo | - |
dc.contributor.affiliatedAuthor | Chung, Jae Yong | - |
dc.contributor.affiliatedAuthor | Cho, Sung Kweon | - |
dc.citation.volume | 22 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 598 | - |
dc.citation.endPage | 605 | - |
dc.identifier.bibliographicCitation | PHARMACOGENETICS AND GENOMICS, Vol.22(8) : 598-605, 2012 | - |
dc.identifier.rimsid | 29545 | - |
dc.type.rims | ART | - |
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