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국내 6개 지역 종합병원에 내원한 소아 알레르기 환자에서의 혈청 Immunoglobulin E 농도에 관한 연구

Other Titles
 The Level of Serum Immunoglobulin E Measured at General Hospitals in Six Regions of Korea in Children with Allergic Diseases. 
 김주화  ;  최경빈  ;  문진화  ;  이하백  ;  김성원  ;  국명희  ;  김자경  ;  김우경  ;  박용민  ;  이소연  ;  홍수종  ;  서주희  ;  김경원  ;  김현희  ;  안강모  ;  박중원  ;  조상헌  ;  이주실  ;  김은진  ;  오재원 
 Pediatric Allergy and Respiratory Disease (소아알레르기 호흡기학회지), Vol.22(1) : 45-53, 2012 
Journal Title
Pediatric Allergy and Respiratory Disease(소아알레르기 호흡기학회지)
Issue Date
Asthma ; Allergic rhinitis ; Atopic dermatitis ; Immunoglobulin E ; Allergen-specific IgE
PURPOSE: We investigated the change in serum total immunoglobulin E (IgE) and allergen-specific IgE according to allergic diseases and age. METHODS: Allergic markers of children under 18 years of age with allergic diseases for the last 5 years were collected from 12 hospitals nationwide. The total data was 9,710. Data about levels of serum total IgE and allergen-specific IgE to 15 common allergens were collected. RESULTS: In children with asthma, serum total IgE was higher in older age than in younger age until age 7 to 12 years, at which time the level was highest (paper radioimmunosorbent test, 526.7 IU/mL; UniCAP, 339.9 IU/mL). The level was lower in older age than that during younger age. This change was similar to that in children with allergic rhinitis and atopic dermatitis. The level was highest at ages 7 to 12 years in children with allergic rhinitis, and at age 10 to 12 years in children with atopic dermatitis. In children with both asthma and allergic rhinitis, as well as in children with all three diseases, the change in serum total IgE was similar to that of children with an isolated disease. The highest level in children with all three diseases was higher than that in children with an isolated disease. The analysis of allergen-specific IgE positivity showed that food allergens were dominant before the age of 2 years, and that aeroallergens such as house dust mites were dominant. CONCLUSION: Serum total IgE in Korean children with allergic diseases was higher in older age than in younger age until the ages of 7 to 12 years, and then the change in total IgE by age was the opposite.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Kyung Won(김경원) ORCID logo https://orcid.org/0000-0003-4529-6135
Park, Jung Won(박중원) ORCID logo https://orcid.org/0000-0003-0249-8749
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