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학동 전기 소아 천식에서 기도가역성 측정을 위한 ΔFEV0.75와 ΔFEV0.5의 유용성

Other Titles
 Usefulness of DeltaFEV0.75 and DeltaFEV0.5 for Airway Reversibility in Preschoolers with Asthma. 
 박현빈  ;  김윤희  ;  백지영  ;  김경원  ;  손명현  ;  김규언 
 Pediatric Allergy and Respiratory Disease (소아알레르기 호흡기학회지), Vol.22(2) : 171-179, 2012 
Journal Title
 Pediatric Allergy and Respiratory Disease  (소아알레르기 호흡기학회지) 
Issue Date
PURPOSE: Preschoolers complete forced expiration in a short time, sometimes more quickly than in 1 second, and therefore the importance of forced expiatory volume in 0.75 seconds (FEV0.75) or forced expiatory volume in 0.5 seconds (FEV0.5) has been raised. The purpose of this study is to evaluate the clinical usefulness of DeltaFEV0.75 and DeltaFEV0.5. METHODS: We analyzed 401 subjects of an asthma group, and 150 subjects of a control group under 7 years of age. RESULTS: DeltaFEV1, DeltaFEV0.75 and DeltaFEV0.5 values of the asthma group were significantly higher than those of the control group, respectively (P<0.0001). DeltaFEV1 (0.60; 95% confidence interval [CI], 0.57 to 0.62), DeltaFEV0.75 (0.61; 0.58 to 0.65), and DeltaFEV0.5 (0.60; 0.56 to 0.64) showed no significant difference in the diagnostic ability of asthma when airway reversibility is defined as DeltaFEVt> or =12%. Cutoff values for asthma were 8.6% in DeltaFEV1, 7.9% in DeltaFEV0.75 and 14.2% in DeltaFEV0.5. DeltaFEV0.75 (0.91; 0.88 to 0.94) showed significantly higher area under curve (AUC) than DeltaFEV0.5 (0.77; 0.73 to 0.82) when stratified by 12%, in predicting airway reversibility defined as DeltaFEV1> or =12%. Cutoff values were 12.3% in DeltaFEV0.75, and 13.4% in DeltaFEV0.5. When airway reversibility is defined as DeltaFEV1> or =8.6%, DeltaFEV0.75 (0.90; 0.87 to 0.92) also showed significantly higher AUC than DeltaFEV0.5 (0.79; 0.75 to 0.82), and Cutoff values were 8.4% in DeltaFEV0.75, and 11.3% in DeltaFEV0.5. CONCLUSION: DeltaFEV0.75 or DeltaFEV0.5 can be a means to replace DeltaFEV1 for diagnosis of asthma and assessment of airway reversibility in preschool children.
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1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실)
Yonsei Authors
김경원(Kim, Kyung Won) ORCID logo https://orcid.org/0000-0003-4529-6135
김규언(Kim, Kyu Earn)
김윤희(Kim, Yoon Hee) ORCID logo https://orcid.org/0000-0002-2149-8501
박현빈(Park, Hyun Bin)
백지영(Baek, Ji Young)
손명현(Sohn, Myung Hyun) ORCID logo https://orcid.org/0000-0002-2478-487X
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